Iranian Biomedical Journal
مجله بیومدیکال ایران
IBJ
Basic Sciences
http://ibj.pasteur.ac.ir
1
admin
1028-852X
2008-823X
-
10.61186/ibj
-
8888
-
en
jalali
1396
6
1
gregorian
2017
9
1
21
5
online
1
fulltext
en
Expression Study and Clinical Correlations of MYC
and CCAT2 in Breast Cancer Patients
Cancer Biology
Cancer Biology
مقاله کامل
Full Length/Original Article
<p><strong>Background: </strong>Colon cancer-associated transcript 2 (<em>CCAT2</em>) is a newly recognized lncRNA transcribed from the 8q24 genomic region. It functions as an oncogene in various types of cancers including breast cancer, in which it affects Wnt/β-catenin pathway. Previous studies have shown a putative interaction between this lncRNA and <em>MYC </em>proto-oncogene. <strong>Methods:</strong> In the current study, we evaluated the expression of <em>CCAT2</em> in breast cancer tissues with regards to the expression of its target <em>MYC</em>. In addition, we assessed the relationship between <em>CCAT2</em> and <em>MYC</em> expression levels in tumor tissues and the clinical prognostic characteristics of breast cancer patients. <strong>Results:</strong> <em>MYC</em> expression levels were significantly up-regulated in tumor tissues compared with adjacent non-cancerous tissues (ANCTs), while such analysis showed no statistically significant difference between these two tissue types in <em>CCAT2</em> expression. Starkly increased <em>CCAT2</em> gene expression levels were found in 12/48 (25%) of cancer tissue samples compared with their corresponding ANCTs. Furthermore, significant inverse correlations were found between <em>CCAT2</em> expression and stage, as well as lymph node involvement. Besides, a significant inverse correlation was found between the relative <em>MYC</em> expression in tumor tissues compared with their corresponding ANCTs and disease stage. <strong>Conclusions:</strong> These results highlight the significance of <em>MYC</em> and <em>CCAT2</em> expressions in the early stages of breast cancer development and suggest a potentially significant role for <em>CCAT2</em> in a subset of breast cancer patients, which could applied as a potential therapeutic target in these patients.</p>
Long non-coding RNA, Breast cancer, c-MYC
303
311
http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-1-659&slc_lang=en&sid=1
Shaghayegh
Sarrafzadeh
100319475328460055478
100319475328460055478
No
Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Lobat
Geranpayeh
100319475328460055479
100319475328460055479
No
Department of Surgery, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran
Behnoosh
Tasharrofi
100319475328460055480
100319475328460055480
No
Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Mohammad
Soudyab
100319475328460055481
100319475328460055481
No
Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Elahe
Nikpayam
100319475328460055482
100319475328460055482
No
Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Mostafa
Iranpour
100319475328460055483
100319475328460055483
No
Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Reza
Mirfakhraie
100319475328460055484
100319475328460055484
No
Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Jalal
Gharesouran
100319475328460055485
100319475328460055485
No
Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Somayyeh
Ghafouri-Fard
100319475328460055486
100319475328460055486
No
Department of Community and Preventive Medicine, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
Soudeh
Ghafouri-Fard
100319475328460055487
100319475328460055487
Yes
Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran