fa Regulation of ERG3, ERG6, and ERG11 Genes in Antifungal-Resistant isolates of Candida parapsilosis Molecular Genetics & Genomics Molecular Genetics & Genomics مقاله کوتاه Short Communication <p><strong>Background: </strong><em>Candida parapsilosis</em> is one of the five common strains of yeasts involved in invasive candidiasis. The expression analysis of sterol biosynthesis pathway genes, which are associated with resistance, can assist the better understanding of antifungal resistance mechanisms.<strong> Methods: </strong>The antifungal susceptibility of 120 clinical <em>C. parapsilosis</em> isolates was examined. The changes in the gene expression related to resistance were analyzed. <strong>Results: </strong>Eight strains were resistant to fluconazole (FLC), itraconazole (ITC), and amphotericin B (AMB). The regulation variations included increased mRNA levels of <em>ERG3</em>, <em>ERG6</em>, and ERG11 and decreased mRNA levels of <em>ERG3</em> and <em>ERG6 </em>in response to FLC. <em>ERG11</em> mRNA level increases in response to ITC and AMB.<strong> Conclusion:</strong> The mechanism of resistance to azoles in <em>C. parapsilosis</em> is very similar to <em>C. Albicans</em>. This feature may help to design new treatment strategy for candidiasis.</p> Candida parapsilosis, Gene expression, Ergosterol biosynthesis 275 281 http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-1-650&slc_lang=fa&sid=1 Ensieh Lotfali No Department of Medical Parasitology and Mycology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran Ali Ghajari No Department of Medical Parasitology and Mycology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran Parivash Kordbacheh No Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran Farideh Zaini No Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran Hossein Mirhendi No Department of Medical Parasitology and Mycology, School of Medicine, Infectious Disease and Tropical Medicine Research Center, Isfahan University of Medical Sciences, Isfahan, Iran Rasoul Mohammadi No Department of Medical Parasitology and Mycology, School of Medicine, Infectious Disease and Tropical Medicine Research Center, Isfahan University of Medical Sciences, Isfahan, Iran Fatemeh Noorbakhsh No Department of Biology, Faculty of Science, Islamic Azad University, Varamin-Pishva, Iran Sassan Rezaie srezaie@tums.ac.ir Yes Division of Molecular Biology, Department of Medical Mycology and Parasitology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran