Iranian Biomedical Journal
مجله بیومدیکال ایران
IBJ
Basic Sciences
http://ibj.pasteur.ac.ir
1
admin
1028-852X
2008-823X
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10.61882/ibj
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8888
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en
jalali
1396
2
1
gregorian
2017
5
1
21
3
online
1
fulltext
en
Comparing Anti-hepatitis B Antibody Level in Iranian Obese or Overweight with Non-obese Cases
Comparing Anti-hepatitis B Antibody Level in Iranian Obese or Overweight with Non-obese Cases
Molecular Immunology & Vaccines
Molecular Immunology & Vaccines
مقاله کوتاه
Short Communication
<p><strong>Background</strong>: There is a controversy about the relation between anti-hepatitis B (anti-HBs) antibody level and obesity. We designed this study to compare the vaccine efficacy in obese/overweight and non-obese cases. <strong>Methods</strong>: In this cross-sectional study, 242 obese/overweight and 85 non-obese individuals were participated. Cases were selected from a referral clinic for obesity and a referral hepatology clinic, both in Tehran, Iran.<br>
<strong>Results</strong>: Obese cases had lower percentage of liver diseases (66.9% vs. 100%, <em>P</em><0.001) but higher hepatitis B vaccination history (74.9% vs. 51.2%, <em>P</em><0.001). Median±inter-quartile range of anti-HBs titer in obese cases was significantly lower than controls (48.5±194.5 vs. 100±557.6, <em>P</em>=0.012). <strong>Conclusion</strong>: The level of anti-HBs surface antigen antibody’s titer in obese cases without liver disease is lower than control group. Therefore, a suitable strategy is needed to overcome this problem, which can be the use of longer needles for vaccination.</p>
Hepatitis B vaccines, Obesity, Liver diseases, Immunosuppressive agent
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http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-1-635&slc_lang=en&sid=1
Ali
Kabir