en Demonstration of Herpes Simplex Virus, Cytomegalovirus and Epstein-Barr Virus in Colorectal Cancer Cancer Biology Cancer Biology مقاله کوتاه Short Communication <p style="direction: ltr; "><strong>Background: </strong>The present study sought to investigate molecular evidence for association between the presence of herpes simplex virus (HSV), cytomegalovirus (CMV), and Epstein-Barr virus (EBV) in CRC and colorectal polyp by using the PCR method in Iran. <strong>Methods: </strong>In this analytical case-control study, we selected 15 patients with CRC, 20 patients with colorectal polyp, and 35 patients without malignancy as controls. After DNA extraction, PCR was used to determine HSV, CMV, and EBV genome by specific primers. Statistical analysis was performed&nbsp;using &chi;² tests.<strong> Results:</strong> Our findings demonstrated that there is no direct molecular evidence to support the association between HSV, CMV, and EBV and human colorectal malignancies. <strong>Conclusion:</strong> The results from&nbsp;this study do not exclude a possible oncogenic role of these viruses in neoplastic development of colon cells.</p> Colorectal cancer, Herpes simplex virus, Cytomegalovirus, Epstein-Bar virus, PCR 302 306 http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-1-600&slc_lang=en&sid=1 Sahar Mehrabani-Khasraghi saharmehrabani1@gmail.com Yes Mitra Ameli No Farzad Khalily No