Iranian Biomedical Journal
مجله بیومدیکال ایران
IBJ
Basic Sciences
http://ibj.pasteur.ac.ir
1
admin
1028-852X
2008-823X
-
10.61186/ibj
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8888
-
en
jalali
1395
8
1
gregorian
2016
11
1
20
5
online
1
fulltext
en
Demonstration of Herpes Simplex Virus, Cytomegalovirus and Epstein-Barr Virus in Colorectal Cancer
Demonstration of Herpes Simplex Virus, Cytomegalovirus and Epstein-Barr Virus in Colorectal Cancer
Cancer Biology
Cancer Biology
مقاله کوتاه
Short Communication
<p style="direction: ltr; "><strong>Background: </strong>The present study sought to investigate molecular evidence for association between the presence of herpes simplex virus (HSV), cytomegalovirus (CMV), and Epstein-Barr virus (EBV) in CRC and colorectal polyp by using the PCR method in Iran. <strong>Methods: </strong>In this analytical case-control study, we selected 15 patients with CRC, 20 patients with colorectal polyp, and 35 patients without malignancy as controls. After DNA extraction, PCR was used to determine HSV, CMV, and EBV genome by specific primers. Statistical analysis was performed using χ<sup>2</sup> tests.<strong> Results:</strong> Our findings demonstrated that there is no direct molecular evidence to support the association between HSV, CMV, and EBV and human colorectal malignancies. <strong>Conclusion:</strong> The results from this study do not exclude a possible oncogenic role of these viruses in neoplastic development of colon cells.</p>
Colorectal cancer, Herpes simplex virus, Cytomegalovirus, Epstein-Bar virus, PCR
302
306
http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-1-600&slc_lang=en&sid=1
Sahar
Mehrabani-Khasraghi
saharmehrabani1@gmail.com
100319475328460055705
100319475328460055705
Yes
Mitra
Ameli
100319475328460055706
100319475328460055706
No
Farzad
Khalily
100319475328460055707
100319475328460055707
No