en Detection of SENV Virus in Healthy, Hepatitis B- and Hepatitis C-Infected Individuals in Yazd Province, Iran Related Fields Related Fields مقاله کامل Full Length/Original Article <p style="direction: ltr; "><strong>Background:</strong> SEN virus (SENV) is the latest virus proposed as a cause of unknown hepatitis cases. Among nine detected genotypes of the virus, genotypes D and H are more frequent in hepatitis cases of unknown origin. The aim of this study was to determine the frequency of SENV-D and SENV-H genotypes in the sera of healthy individuals and hepatitis B and C patients. <strong>Methods:</strong> Totally, 200 serum samples from healthy individuals as well as 50 hepatitis B and 50 hepatitis C patients were collected. Anti-HCV (hepatitis C virus), anti-human immunodeficiency virus, hepatitis B surface antigen and anti-HBV (hepatitis B virus) core antigen were detected, and serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were measured. Viral DNA was subjected to nested PCR. Fisher&#39;s exact and unpaired ANOVA tests were used for statistical analyses. <strong>Results:</strong> SENV was detected in 90%, 66%, and 46% of the healthy individuals HBV and HCV-positive individuals, respectively. The frequency of SENV and its two genotypes were significantly lower in hepatitis B and hepatitis C patients (<em>P</em><0.01). Also, the frequency of SENV-H was higher than SENV-D in all studied groups. In SENV-positive HBV patients, the level of ALT and AST enzymes were significantly less than SENV-negative patients (<em>P</em><0.05). It was the same for SENV-H-negative and -positive cases. <strong>Conclusions:</strong> The levels of liver enzymes were significantly lower in HBV patients co-infected with SENV compared to HBV patients (<em>P</em><0.05), indicating a positive impact of the virus in liver pathology by decreasing liver damage and thus decreasing the liver enzymes.</p> <p></p> Hepatitis B virus (HBV), Hepatitis C virus (HCV), SEN virus (SENV) 168 174 http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-1-598&slc_lang=en&sid=1 Sayedeh Azimeh Hosseini No Majid Bouzari bouzari@sci.ui.ac.ir Yes