en Association of two Common Single Nucleotide Polymorphisms (SNPs +45T/G and +276G/T) of ADIPOQ Gene on Coronary Artery Disease in Type 2 Diabetic Patients Related Fields Related Fields مقاله کامل Full Length/Original Article <p style="direction: ltr; "><strong>Background:</strong> Adiponectin, an adipocyte-secreted hormone, is known to have anti-atherogenic, anti-inflammatory, and anti-diabetic properties. In the present study, the association between two common single nucleotide polymorphisms (SNPs) (+45T/G and +276G/T) of <em>ADIOPQ</em> gene and coronary artery disease (CAD) was assessed in the subjects with type 2 diabetes (T2DM). <strong>Methods:</strong> Genotypes of two SNPs were determined by polymerase chain reaction-restriction fragment length polymorphism in 200 subjects with T2DM (100 subjects with CAD and 100 without CAD). <strong>Results:</strong> The frequency of TT genotype of +276G/T was significantly elevated in CAD compared to controls (&chi;²=7.967, <em>P</em>=0.019). A similar difference was found in the allele frequency of +276G/T between two groups (&chi;²=3.895, <em>P</em>=0.048). The increased risk of CAD was associated with +276 TT genotype when compared to reference GG genotype (OR=5.158; 95% CI=1.016-26.182, <em>P</em>=0.048). However, no similar difference was found in genotype and allele frequencies of SNP +45T/G between two groups. There was a CAD protective haplotype combination of +276 wild-type and +45 mutant-type allele (276G-45G) (OR=0.37, 95% CI=0.16-0.86, <em>P</em>=0.022) in the subject population. <strong>Conclusion:</strong> Our findings indicated that T allele of SNP +276G/T is more associated with the increased risk of CAD in subjects with T2DM. Also, a haplotype combination of +45G/+276G of these two SNPs has a protective effect on the risk of CAD.</p> Adiponectin, Type 2 diabetes, Cronary artery disease, Single nucleotide polymorphisms 152 160 http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-1-592&slc_lang=en&sid=1 Ghorban Mohammadzadeh mohammadzadeh@ajums.ac.ir Yes Mohammad-Ali Ghaffari No Habib Heibar No Mohammad Bazyar No