Iranian Biomedical Journal
مجله بیومدیکال ایران
IBJ
Basic Sciences
http://ibj.pasteur.ac.ir
1
admin
1028-852X
2008-823X
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10.61186/ibj
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8888
-
en
jalali
1394
1
1
gregorian
2015
4
1
19
2
online
1
fulltext
en
بهبود بقای بافتی فلاپ های پوستی با مهارکننده های 5-آلفا ردوکتاز: مشارکت احتمالی نیتریک اکسید و نیتریک اکسید سنتاز القایی
Improvement of Tissue Survival of Skin Flaps by 5α-Reductase Inhibitors: Possible Involvement of Nitric Oxide and Inducible Nitric Oxide Synthase
Related Fields
Related Fields
مقاله کامل
Full Length/Original Article
Background: Skin flap grafting is a popular approach for reconstruction of critical skin and underlying soft tissue injuries. In a previous study, we demonstrated the beneficial effects of two 5α-reductase inhibitors, azelaic acid and finasteride, on tissue survival in a rat model of skin flap grafting. In the current study, we investigated the involvement of nitric oxide and inducible nitric oxide synthase (iNOS) in graft survival mediated by these agents. Methods: A number of 42 male rats were randomly allocated into six groups: 1, normal saline topical application 2, azelaic acid (100 mg/flap) 3, finasteride (1 mg/flap) 4, injection of L-NG-nitroarginine methyl ester (L-NAME) (i.p., 20 mg/kg) 5, L-NAME (20 mg/kg, i.p.) + azelaic acid (100 mg/flap, topical) 6, L-NAME (20 mg/kg, i.p.) + finasteride (1 mg/flap, topical). Tissue survival, level of nitric oxide, and iNOS expression in groups were measured. Results: Our data revealed that azelaic acid and finasteride significantly increased the expression of iNOS protein and nitric oxide (NO) levels in graft tissue (P < 0.05). These increases in iNOS expression and NO level were associated with higher survival of the graft tissue. Conclusion: It appears that alterations of the NO metabolism are implicated in the azelaic acid- and finasteride-mediated survival of the skin flaps.
Finasteride, Azelaic acid, Surgical flaps, Nitric oxide, Nitric oxide synthase Type II
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http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-1-545&slc_lang=en&sid=1
Ali Asghar
Karimi
علی اصغر
کریمی
100319475328460055977
100319475328460055977
No
Marjan
Ajami
مرجان
عجمی
100319475328460055978
100319475328460055978
No
Yasin
Asadi
یاسین
اسدی
100319475328460055979
100319475328460055979
No
Nahid
Aboutaleb
ناهید
ابوطالب
100319475328460055980
100319475328460055980
No
Fazel
Gorjipour
فاضل
گرجی پور
100319475328460055981
100319475328460055981
No
Roya
Malekloo
رویا
ملک لو
100319475328460055982
100319475328460055982
No
Hamidreza
Pazoki-Toroudi
حمیدرضا
پازوکی طرودی
hrptoroudi@gmail.com
100319475328460055983
100319475328460055983
Yes