Iranian Biomedical Journal
مجله بیومدیکال ایران
IBJ
Basic Sciences
http://ibj.pasteur.ac.ir
1
admin
1028-852X
2008-823X
-
10.61186/ibj
-
8888
-
en
jalali
1394
1
1
gregorian
2015
4
1
19
2
online
1
fulltext
en
نقش گیرنده های گابا B و ال آرزنینین در گشادی عروقی القا شده توسط گابا در عروق رتهای غیر دیابتی و دیابتی القا شده توسط استرپتوزوتوسین
Role of GABAB Receptor and L-Arg in GABA- Induced Vasorelaxation in Non-diabetic and Streptozotocin-Induced Diabetic Rat Vessels
Related Fields
Related Fields
مقاله کامل
Full Length/Original Article
Background: Hypertension is considered an independent risk factor for cardiovascular mortality in diabetic patients. The present study was designed to determine the role of gamma amino butyric acid B (GABAB) receptor and L-arginine (L-Arg) in GABA-induced vasorelaxation in normal and streptozotocin-induced diabetic rat vessels. Methods: Diabetes was induced by a single i.p. injection of streptozotocin (STZ, 60 mg/kg). Eight weeks later, superior mesenteric arteries of all groups were isolated and perfused according to the McGregor method. Results: Baseline perfusion pressure of STZ diabetic rats was significantly higher than non-diabetic rats in both intact and denuded endothelium. In the presence of faclofen, a selective GABAB receptor blocker, GABA-induced relaxation in intact and denuded endothelium mesenteric beds of STZ diabetic rats was suppressed, but this response in non-diabetic rats was not suppressed. Our results showed that in the presence of L-Arg, a nitric oxide precursor, GABA induced vasorelaxation in both diabetic and non-diabetic vessels. Conclusion: From the results of this study, it may be concluded that the vasorelaxatory effect of GABA in diabetic vessel is mediated by the GABAB receptor and nitric oxide, but it seems that in non-diabetic vessel GABAB receptor does not play any role in GABA-induced vasorelaxation, but nitric oxide induced GABA relaxation in non-diabetic vessel.
Gamma amino butyric acid (GABA), Diabetes, GABAB receptor
91
95
http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-1-542&slc_lang=en&sid=1
Fatemah
Kharazmi
فاطمه
خوارزمی
100319475328460055965
100319475328460055965
No
Nepton
Soltani
نپتون
سلطانی
neptun.soltani@gmail.com
100319475328460055966
100319475328460055966
Yes
Sana
Rezaei
سنا
رضایی
100319475328460055967
100319475328460055967
No
Mansoor
Keshavarz
منصور
کشاورز
100319475328460055968
100319475328460055968
No
Leila
Farsi
لیلا
فارسی
100319475328460055969
100319475328460055969
No