Iranian Biomedical Journal
مجله بیومدیکال ایران
IBJ
Basic Sciences
http://ibj.pasteur.ac.ir
1
admin
1028-852X
2008-823X
-
10.61186/ibj
-
8888
-
en
jalali
1394
7
1
gregorian
2015
10
1
19
4
online
1
fulltext
en
اثرات غیر فعال شدن موقت ناحیه تگمنتال شکمی در بیان و اکتساب ترجیح مکان شرطی القا شده در موش صحرایی
Effect of Transient Inactivation of Ventral Tegmental Area on the Expression and Acquisition of Nicotine-Induced Conditioned Place Preference in Rats
Medical Biotechnology
Medical Biotechnology
مقاله کامل
Full Length/Original Article
<p>Background: Nicotine can activate dopaminergic neurons within the ventral tegmental area (VTA). However, there is no evidence about complete inhibition of VTA on nicotine reinforcement. Methods: in the present study, we used conditioned-place preference (CPP) method to study the effect of transient inhibition of left and/or right side of the VTA by lidocaine on nicotine reward properties. Male Wistar rats seven days after recovery from surgery and cannulation were conditioned to nicotine (1.5 mg/kg) in an unbiased designed CPP apparatus. Five min before each nicotine injection in conditioning phase, lidocaine (2%) was administers either uni- or bi-laterally into the VTA (0.5µl/rat). Results: results revealed that lidocaine administration into the left but not right side of the VTA reduced nicotine CPP significantly. The reduction was potentiated when lidocaine injected in to both sides of the VTA. In addition, the number of compartment crossing was reduced when lidocaine injected in both side of VTA as well as left side. On the other hand, rearing was reduced when lidocaine injected to the right but not left side of VTA. At last, sniffing was reduced only in the group in which received lidocaine in both side of VTA. Sniffing and rearing increased in the group in which received lidocaine in right side. Conclusion: It is concluded that the right and left side of VTA play different role in nicotine-induced activity and reward.</p>
Ventral tegmental area (VTA), Lidocaine, Nicotine, Rats
214
219
http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-1-541&slc_lang=en&sid=1
Durna
Chalabi-Yani
درنا
چابیانی
100319475328460055870
100319475328460055870
No
Hedayat
Sahraei
هدایت
صحرایی
100319475328460055871
100319475328460055871
No
Gholam Hossein
Meftahi
غلام حسین
مفتاحی
meftahi208@yahoo.com
100319475328460055872
100319475328460055872
Yes
Seydeh Bentolhuda
Hosseini
سیده بنت الهدی
حسینی
100319475328460055873
100319475328460055873
No
Sara
Sadeghi-Gharajehdaghi
سارا
صادقی قرجی دهی
100319475328460055874
100319475328460055874
No
Hengameh
Ali Beig
هنگامه
علی بیگ
100319475328460055875
100319475328460055875
No
Zahra
Bourbour
زهرا
بوربور
100319475328460055876
100319475328460055876
No
Mina
Ranjabaran
مینا
رنجبران
100319475328460055877
100319475328460055877
No