Iranian Biomedical Journal
مجله بیومدیکال ایران
IBJ
Basic Sciences
http://ibj.pasteur.ac.ir
1
admin
1028-852X
2008-823X
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10.61186/ibj
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8888
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en
jalali
1385
10
1
gregorian
2007
1
1
11
1
online
1
fulltext
en
حذف سنتز سروتونین با اثر CPA متغیری در EEG موش صحرایی ایجاد میکند
Depletion of Serotonin Synthesis with p-CPA Pretreatment Alters EEG in Urethane Anesthetized Rats under Whole Body Hyperthermia
Related Fields
Related Fields
مقاله کامل
Full Length/Original Article
Serotonin is believed as an important factor in brain function. The role of serotonin in cerebral psycho-patho-physiology has already been well established. However, the function of serotonin antagonist in anesthetized subjects under hyperthermia has not been studied properly. Methods: Experiments were performed in three groups of urethane-anesthetized rats, such as: (i) control group, (ii) whole body hyperthermia group and (iii) p-CPA (para-Chlorophenylalanine) pretreated hyperthermia group. Hyperthermia was produced by subjecting the rats to high ambient temperature of 38 ± 1ºC (relative humidity 45-50%). Each group was divided for EEG (electroencephalogram) study and for determination of edematous swelling in the brain. Results: Urethane anesthetized rats under hyperthermia show highly significant reduction in their survival time. The body temperature recorded during the hyperthermia was observed with significant and linear rise with marked increase in brain water content, which was analyzed just after the death of the subjects. The results of the electroencephalographic study in urethane-anesthetized rats recorded before death indicate that brain function varies in systematic manner during hyperthermia as sequential changes in EEG patterns were observed. However, a serotonin antagonist, p-CPA pretreatment increases the survival time with significant reduction in edematous swelling in brain but it does not affect the relationship between the core body temperature and the brain cortical potentials as observed in urethane anesthetized subjects exposed to whole body hyperthermia. The core body temperature in p-CPA pretreated rats show non-linear relationship with respect to the exposure time as it was observed in drug untreated subjects. Conclusion: The findings of the present study indicate that although pretreatment of p-CPA in rats has a marked correlation between the extravasations of the blood-brain barrier under hyperthermia but shows minimum effect on the EEG in a model of hyperthermia under irreversible anesthesia.
Hyperthermia, Urethane anesthesia, Para-Chlorophenylalanine (p-CPA), Electroencephalogram (EEG), Brain edema
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http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-1-82&slc_lang=en&sid=1
Rakesh Kumar
Sinha
Rakesh Kumar
Sinha
rksinha_res@rediffmail.com
100319475328460057205
100319475328460057205
Yes
Yogender
Aggarwal
Yogender
Aggarwal
100319475328460057206
100319475328460057206
No