en تاثیر تجویز اسید آسکوربیک و سیر بر آپوپتوز ناشی از تماس با سرب در شبکیه چشم نوزادان رت Related Fields Related Fields مقاله کامل Full Length/Original Article Introduction: Lead toxicity induces retinal cell apoptosis. Vitamin C and garlic may decrease lead-induced apoptosis. This study was undertaken to investigate vitamin C and garlic protective effects on lead-induced apoptosis in eye retina. Methods: Pregnant Wistar rats (n = 72) were divided randomly into 9 groups: (L) treated rats with lead acetate in drinking water and (L+AA) with leaded water and vitamin C intraperitoneally(L+G), the rats received leaded-water and garlic juice via gavage (L+AA+G) treated rats with leaded water, ascorbic acid, and garlic juice, (AA) with ascorbic acid, and (G) with garlic juice (AA+G) treated rats with vitamin C and garlic juice and (Sh) with tap water plus normal hydrogen chloride (HCl) and glucose normal (N). After 21-day lactation, blood lead level (BLL) in rats was measured, and then their offspring and the rat offspring&#39;s eyes were removed and processed for using TUNEL method. TUNEL positive cells in the eye retina were counted and all groups were compared. Results: BLL increased in L group compared to the control groups and decreased significantly in L + G, L + AA, and L+ AA + G groups compared to L group (P<0.05). TUNELL positive cell number in eye retina significantly increased in L group compared to control groups (P<0.05) and decreased in L+ G, L+ AA, and L+AA + G groups compared to L group (P<0.05). Conclusion: Garlic juice and ascorbic acid administration during pregnancy and lactation may protect lead-induced apoptosis in rat offspring&#39;s eye retina. Lead, Garlic, Ascorbic acid, Apoptosis, Retina 206 213 http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-1-487&slc_lang=en&sid=1 Elnaz Khordad الناز خرداد No Alireza Fazel علیرضا فاضل No Alireza Ebrahimzadeh Bideskan علیرضا ابراهیم زاده بیدسکان EbrahimzadehBA@mums.ac.ir Yes