RT - Journal Article T1 - Seroprevalence of Herpes Simplex Viruses Types 1 and 2 in a Population, Age 15-35 Years, of Mashhad City JF - انستیتو-پاستور-ایران YR - 2023 JO - انستیتو-پاستور-ایران VO - 27 IS - 2 UR - http://ibj.pasteur.ac.ir/article-1-3828-en.html SP - 152 EP - 157 K1 - Herpes Simplex Virus Type 1 K1 - Herpes Simplex Virus Type 2 K1 - Iran K1 - Seroepidemiology AB - Background: Considering the high prevalence and clinical importance of herpes simplex virus (HSV) infection worldwide, we aimed to evaluate the seroprevalence of HSV-1 and HSV-2 in a population aged between 15 and 35 years in Mashhad, Iran. Methods: This cross-sectional study was conducted on 916 cases composed of 288 (31.4%) men and 628 (68.6%) women. Using ELISA method, the presence of IgM and IgG antibodies against HSV-1 and HSV-2 was assessed. Results: Among the population studied, 681 (74.3%) cases were positive for anti-HSV antibodies, while 235 (25.7%) cases were negative. Moreover, no IgMs were found and all positive subjects had IgG antibodies. Age (p < 0.001), occupation (p < 0.001), education (p = 0.006), smoking (p = 0.029), and BMI (p = 0.004) demonstrated a significant association with HSV-1 and HSV-2 infection. Conclusion: Our study indicates a high seroprevalence of HSV infection; however, there was no cases positive for IgM antibodies, suggesting the high prevalence of latent infection. LA eng UL http://ibj.pasteur.ac.ir/article-1-3828-en.html M3 10.61186/ibj.3828 ER -