AU - Abdellahi, latifeh AU - Iraji, fariba AU - mahmoudabadi, anahita AU - hejazi, seyed hossein TI - Vaccination in Leishmaniasis: A Review Article PT - JOURNAL ARTICLE TA - انستیتو-پاستور-ایران JN - انستیتو-پاستور-ایران VO - 26 VI - 1 IP - 1 4099 - http://ibj.pasteur.ac.ir/article-1-3523-en.html 4100 - http://ibj.pasteur.ac.ir/article-1-3523-en.pdf SO - انستیتو-پاستور-ایران 1 AB  - Leishmaniasis is caused by protozoan Leishmania parasites that are transmitted through female sandfly bites. The disease is predominantly endemic to the tropics and semi-tropics and has been reported in more than 98 countries. Due to the side effects of anti-Leishmania drugs and the emergence of drug-resistant isolates, there is currently no encouraging prospect of introducing an effective therapy for the disease. Hence, it seems that the key to disease control management is the introduction of an effective vaccine, particularly against its cutaneous form. Advances in understanding underlying immune mechanisms are feasibale using a variety of candidate antigens, including attenuated live parasites, crude antigens, pure or recombinant Leishmania proteins, Leishmania genes encoding protective proteins, as well as immune system activators from the saliva of parasite vectors. However, there is still no vaccine against different types of human leishmaniasis. In this study, we review the works conducted or being performed in this field. CP - IRAN IN - LG - eng PB - انستیتو-پاستور-ایران PG - 1 PT - Review Article YR - 2022