%0 Journal Article %A Díaz-García, Alexis %A González, Gilmara Pimentel %A Bernabeu, Tais Basaco %A Aurrecochea, Juan C. Rodríguez %A Sánchez, Hermis Rodríguez %A Monzón, Iraida Sánchez %A Gómez, Maikel Hernández %A Torres, Caridad Rodríguez %A Capote, Maria Regla Rodríguez %A Orellanes, Irania Guevara %T Pharmacokinetics and Biodistribution of Rhopalurus junceus Scorpion Venom in Tumor-Bearing Mice after Intravenous and Oral Administration %J Iranian Biomedical Journal %V 23 %N 4 %U http://ibj.pasteur.ac.ir/article-1-2677-en.html %R 10.29252/ibj.23.4.287 %D 2019 %K Intravenous, Mice, Oral administration, Radioactivity, Scorpion venom, %X Introduction: Rhopalurus junceus scorpion venom has shown potential for anticancer treatment. However, there are no scientific evidence about venom pharmacokinetic (PK) and biodistribution (BD) in tumor-bearing mice. Methods: 131I-labeled venom was administrated by intravenous (IV) and oral (PO) routes at the single dose of 12.5 mg/kg. Mice were sacrificed and blood samples, major organs, and tumor were taken at 10, 20, 40, 90, 180, 300, 480, and 1440 min. Results: For IV route, maximum peak concentration (Cmax), elimination half-lives, total body clearance (CL), distribution volume (Vd), mean residence time (MRT), and area under curve (AUC) were 21.77 ± 2.45 %Dosis·h/mL, 12.65 ± 2.1 h, 4.59 ± 0.23 mL/h, 83.80 ± 12 mL, 12.49 ± 2.71 h, and 21.77 ± 2.45 %Dosis·h/mL, respectively. For PO route, they were 0.60 ± 0.07 %Dosis·h/mL, 9.33 ± 1.35 h, 36.94 ± 4.01 mL/h, 497.33 ± 30 mL, 12.40 ± 1.87 h, and 6.89 ± 1.18 %Dosis·h/mL, respectively. PK parameters (Cmax, CL, Vd, and AUC) showed significant differences between IV and PO routes. Bioavailability was 31.6 ± 4% for PO dose. Kidney, stomach, liver, and lung for IV and stomach, kidney, spleen, and lung for PO routes showed the major uptakes for 131I-labeled venom. In tumor tissue, after the maximum uptake for both routes, there was a consistent behavior of radioactivity respect to the major organs during the first 480 min. Conclusion: The PK and BD of R. junceus venom in mice depend on the administration route. These data represent a starting point for future experiments with this scorpion venom in experimental models of cancer. %> http://ibj.pasteur.ac.ir/article-1-2677-en.pdf %P 287-296 %& 287 %! PK and BD of R. junceus Venom in Tumor-Bearing Mice %9 Full Length/Original Article %L A-10-1-768 %+ Research Department, Laboratories of Biopharmaceuticals and Chemistries Productions (LABIOFAM), Havana, Cuba %G eng %@ 1028-852X %[ 2019