TY - JOUR T1 - Up-Regulation of miR-21, miR-25, miR-93, and miR-106b in Gastric Cancer TT - JF - انستیتو-پاستور-ایران JO - انستیتو-پاستور-ایران VL - 22 IS - 6 UR - http://ibj.pasteur.ac.ir/article-1-2441-en.html Y1 - 2018 SP - 367 EP - 373 KW - Biomarkers KW - microRNAs KW - Stomach cancer N2 - Background: Differential expression profile of microRNAs (miRNAs) could be a diagnosis signature for monitoring gastric cancer (GC) progression. In this study, we focus on the comparison of expression levels of miR-21, miR-25, miR-93, miR-106b, and miR-375 during the sequential pattern of GC development, including normal gastric, gastric dysplasia, and GC sample. Methods: We used SYBR Green-based quantitative-PCR to quantify miRNAs expression. Results: Our analysis revealed the increased expression levels of miR-21 (p = 0.034), miR-25 (p = 0.0003), miR-93 (p = 0.0406), and miR-106b (p = 0.023) in GC samples. In addition, GC patients with positive lymph node metastasis showed the up-regulation of miR-25, miR-93, and miR-106b (p < 0.05). Conclusion: Our findings suggested that the expression of miR-21, miR-25, miR-93, and miR-106b altered in GC, and some of them may be further investigated as biomarkers for GC early detection and prognosis prediction. M3 10.29252/ibj.22.6.367 ER -