TY - JOUR T1 - Prevention of Nonalcoholic Steatohepatitis in Rats by Two Manganese-Salen Complexes TT - پیشگیری از استئاتوهپاتیت غیر الکلی در رت توسط دو کمپلکس منگنز سالن JF - انستیتو-پاستور-ایران JO - انستیتو-پاستور-ایران VL - 18 IS - 1 UR - http://ibj.pasteur.ac.ir/article-1-1092-en.html Y1 - 2014 SP - 41 EP - 48 KW - Fatty liver KW - Oxidative stress KW - Antioxidants N2 - Background: Nonalcoholic steatohepatitis (NASH), a progressive stage of nonalcoholic fatty liver disease (NAFLD), is characterized by steatosis with inflammation. Investigations have suggested that oxidative stress may play an important role in the progress of NAFLD to NASH. To provide further insights into beneficial effects of antioxidants in NASH prevention, we employed two manganese-superoxide dismutase/catalase mimetics, manganese N,N`-bis(salicyldene) ethylene diamine chloride (EUK-8) and manganese-3-methoxy N,N`-bis(salicyldene)ethylenediamine chloride (EUK-134), as two salen representatives and vitamin C as the standard antioxidant. Methods: Experimental NASH was induced in Male N-Mary rats by feeding a methionine/choline-deficient (MCD) diet to rats for 10 weeks. The rats (n = 5, 30 mg/kg/day) were randomly assigned to receive vitamin C, EUK-8, EUK-134 or vehicle orally. Results: Administration of salens together with the MCD diet reduced the serum aminotransferases, glutathione transferase and alkaline phosphatase, cholesterol, and LDL contents. In addition, the EUK-8 and EUK-134 improved NASH pathological features in liver of MCD-fed rats. Conclusion: EUK-8 and EUK-134 supplementation reduces NASH-induced abnormalities, pointing out that antioxidant strategy could be beneficial for prevention of NASH. M3 10.6091/ibj.1201.2013 ER -