TY - JOUR T1 - Microglial Activation in Rat Experimental Spinal Cord Injury Model TT - فعالیت سلول های میکروگلیال درمدل تجربی ضایعه نخاعی موش صحرایی JF - انستیتو-پاستور-ایران JO - انستیتو-پاستور-ایران VL - 17 IS - 4 UR - http://ibj.pasteur.ac.ir/article-1-1025-en.html Y1 - 2013 SP - 214 EP - 220 KW - Spinal cord injuries KW - Inflammation KW - Microglia KW - Macrophages N2 - Background: The present study was designed to evaluate the secondary microglial activation processes after spinal cord injury (SCI). Methods: A quantitative histological study was performed to determine ED-1 positive cells, glial cell density, and cavitation size in untreated SCI rats at days 1, 2, and 4, and weeks 1, 2, 3, and 4. Results: The results of glial cell quantification along the 4900-µm long injured spinal cord showed a significant increase in glial cell density percentage at day 2 as compared to other days. Whereas the highest increase in ED-1 immunoreactive cells (monocyte/phagocyte marker in rats) was observed at day 2 (23.15%) post-injury. Evaluation of cavity percentage showed a significant difference between weeks 3 and 4 post-injury groups. Conclusions: This study provides a new insight into the multiphase immune response to SCI, including cellular inflammation, macrophages/microglia activation, glial cell density, and cavitation. Better understanding of the inflammatory processes associated with acute SCI would permit the development of better therapeutic strategies. M3 10.6091/ibj.1213.2013 ER -