RT - Journal Article T1 - Functional and Physical Consequence of Human Immunodefficiency Virus Transactivator TAT Interaction with Human Cell Cycle Regulator p53 JF - انستیتو-پاستور-ایران YR - 1997 JO - انستیتو-پاستور-ایران VO - 1 IS - 4 UR - http://ibj.pasteur.ac.ir/article-1-873-en.html SP - 1 EP - 9 K1 - HIV K1 - TAT K1 - Transcription K1 - Cell cycle K1 - p53 AB - Human immunodeficiency virus (HIV) transactivator Tat is a potent activator of both viral and cellu‌lar genes. Tat has also been implicated in the development of AIDS-related malignancy. Here, we show that Tat physically and functionally is able to sequester the cell cycle check point protein p53. This sequestration results in non-functional promoter activity of cyclin-dependent kinase/cyclin in‌hibitor, namely p21 (Waf1). Therefore, it is proposed that a Tat/p53 complex in vivo may deregulate p53 responsive genes, hence allowing for deregulation of check point, which may lead to development of malignancies. LA eng UL http://ibj.pasteur.ac.ir/article-1-873-en.html M3 ER -