TY - JOUR T1 - Significant Changes in the Activity of L-Glutamic Acid Decarboxylase of Mouse Hypothalamus After Peripheral Injection of Cholecystokinin-8 and Caerulein TT - JF - انستیتو-پاستور-ایران JO - انستیتو-پاستور-ایران VL - 3 IS - 1 UR - http://ibj.pasteur.ac.ir/article-1-857-en.html Y1 - 1999 SP - 47 EP - 51 KW - Caerulein KW - Cholecystokinin-8 KW - GABA KW - L-Glutamic acid decarboxylase N2 - The activity of one of the metabolizing enzymes of - aminobutyric acid, (GABA), was determined in mouse hypothalamus after peripheral injections of cholecystokinin-8 (CCK-8) and caerulein (CLN). The activity of this rate-limiting enzyme, L-glutamic acid decarboxylase, (GAD), did not change thirty minutes after peripheral injections of either CCK-8 or CLN in doses of 50g/kg body weight. However, the activity of GAD started to increase 24 hours after injection and continued to increase by 15 to 17%, five days after injections. Based on the in vitro models, it has been shown that there are no direct interactions between CCK-8 and CLN and the enzyme GAD. These data probably support indirect but specific interactions between CCK-8, CLN and the enzyme GAD. M3 ER -