TY - JOUR T1 - HIV-Derived Lentiviral Vectors: Current Progress toward Gene Therapy and DNA Vaccination TT - JF - انستیتو-پاستور-ایران JO - انستیتو-پاستور-ایران VL - 2 IS - 3 UR - http://ibj.pasteur.ac.ir/article-1-854-en.html Y1 - 1998 SP - 95 EP - 103 KW - HIV-Lentiviral Vectors KW - Gene Therapy KW - DNA Vaccination KW - Gene Delivery N2 - Lentiviral vectors are promising gene delivery tools capable of transducing a variety of dividing and non-dividing cells, including pluripotent stem cells which are refractory for transduction by murine retroviruses. Although there is a growing debate on the safety of lentiviral vectors for gene transfer, in particular for those derived from human immunodeficiency viruses, type one (HIV-1) and type two (HIV-2), these vectors are envisioned to possess several advantages. Importantly, they can be utilized not only for transducing specific target cells or for in vivo gene therapy of HIV infection and acquired immunodeficiency syndrome (AIDS), but also in a pseudotype recombinant form can be used for different target cells including neurological and cancer cells. For HIV-2, the most com-pelling advantages are: (i) its reduced ability to recombine with resident HIV-1 genome (ii) its ability to induce in recipients antibodies which can be distinguished from host immune response to HIV-1 (iii) HIV-2 is apparently less pathogenic and (iv) may downregulate HIV-1 expression. This review will summarize new developments on HIV-1 vectors, while focusing on alternate strategies toward developing HIV-2-based vectors. M3 ER -