%0 Journal Article %A Heidaran, mohammad A. %T Tissue Engineering: A Biological Solution for Tissue Damage, Loss or End Stage Organ Failure %J Iranian Biomedical Journal %V 4 %N 1 %U http://ibj.pasteur.ac.ir/article-1-826-en.html %R %D 2000 %K Extracellular matrices, Stem cells, Biomaterial, Tissue engineering, Growth factors, %X In recent years the science of tissue engineering has emerged as a powerful tool for the development of a novel set of tissue replacement parts and technologies. Recent advances in the fields of biomaterials, stem cell technologies, growth factor field and biomimetics have created a unique set of opportunities for investigators to fabricate lab-grown tissues from combination of extracellular matrices (scaffolds), cells, and bioactive molecules. Despite these breakthrough advances, the major challenges facing this new emerging field of bioengineering remain unresolved as lab-grown tissues still exhibit a general lack of functional and biomechanical stability needed for transplantation. A successful strategy to develop true human replacement parts requires a multidisciplinary approach that converges recent advances in tissue, matrix, growth factor and developmental biology with recent technological breakthroughs in tissueinformatics, bioinformatics, highthrouput combinatorial chemistry and stem cell technologies. %> http://ibj.pasteur.ac.ir/article-1-826-en.pdf %P 1-5 %& 1 %! %9 Review Article %L A-10-1-394 %+ %G eng %@ 1028-852X %[ 2000