%0 Journal Article %A Sayyah, Mohammad %A Peirovi, Afshin %A Kamalinejad, Mohammad %T Anti-Nociceptive Effect of the Fruit Essential Oil of Cuminum cyminum L. in Rat %J Iranian Biomedical Journal %V 6 %N 4 %U http://ibj.pasteur.ac.ir/article-1-560-en.html %R %D 2002 %K Anti-nociceptive effect, Essential oil, Cuminum cyminum Linn, %X Cuminum cyminum Linn. (Umbelliferae) is a plant, which has been used as a toothache remedy in folk medicine of Iran. In this study, the potential anti-nociceptive and anti-inflammatory activities of the fruit essential oil of C. cyminum has been evaluated in chemical (formalin test) and thermal (tail-flick test) models of nociception and formalin model of acute inflammation in rats and mice. The essential oil at the doses ranging between 0.0125 and 0.20 ml/kg exhibited a significant and dose-dependent analgesic effect in the model of chronic and inflammatory pain. However, the essential oil was devoid of anti-inflammatory activity. Moreover, the essential oil had no analgesic effect in tail flick test as a model of acute pain. The LD50 value of 0.59 ml/kg was obtained for the essential oil. This low toxicity of the essential oil makes it worthy for further studies %> http://ibj.pasteur.ac.ir/article-1-560-en.pdf %P 141-145 %& 141 %! %9 Full Length/Original Article %L A-10-1-294 %+ %G eng %@ 1028-852X %[ 2002