TY - JOUR JF - انستیتو-پاستور-ایران JO - IBJ VL - 6 IS - 4 PY - 2002 Y1 - 2002/10/01 TI - Study of the Heat-Treated Human Albumin Stabilization by Caprylate and Acetyltryptophanate TT - Study of the Heat-Treated Human Albumin Stabilization by Caprylate and Acetyltryptophanate N2 - Sodium salt of N-acetyl-DL-tryptophan (AT) and octanoic acid (caprylic acid CA) individually and in combination were studied as thermal stabilizer with different concentrations in heat treatment of human albumin solution. HPLC protein profiles before pasteurization of albumin showed less than 1% polymer. In free stabilizer albumin solution during pasteurization visible clot was formed. But by using variation of the above mentioned stabilizers, the amount of polymer was increased to about 4% during pasteurization (60° C, 10 h). By increasing the heat to the visible clot formation point, the most effective stabilizer against visible clot formation was found to be CA. However, in drug formulation it is important to choose the variety and concentration of stabilizers in accordance with regulations. SP - 135 EP - 140 AU - Mousavi Hosseini, Kamran AU - Rezvan, Houri AU - Motalleb, Zabihollah AU - Chabokpey, Sedigheh AU - Mirbod, Vida AD - KW - Octanoate KW - Acetyltryptophanate KW - Albumin stabilizer UR - http://ibj.pasteur.ac.ir/article-1-559-en.html ER -