AU - Ghatreh Samani, Keihan AU - Noori, Mohammad AU - Rohbani Nobar, Mohammad AU - Hashemzadeh Chaleshtori, Morteza AU - Farrokhi, Effat AU - Darabi Amin, Masoud TI - I405V and -629C/A Polymorphisms of the Cholesteryl Ester Transfer Protein Gene in Patients with Coronary Artery Disease PT - JOURNAL ARTICLE TA - انستیتو-پاستور-ایران JN - انستیتو-پاستور-ایران VO - 13 VI - 2 IP - 2 4099 - http://ibj.pasteur.ac.ir/article-1-62-en.html 4100 - http://ibj.pasteur.ac.ir/article-1-62-en.pdf SO - انستیتو-پاستور-ایران 2 AB  - Background: Cholesteryl ester transfer protein (CETP) plays a main role in high-density lipoprotein metabolism. CETP gene possesses several single nucleotide polymorphisms which have been associated with plasma high-density lipoprotein cholesterol (HDL-C) concentrations. The aim of this study was to determine the association of CETP -629C/A and I405V polymorphisms with coronary artery disease (CAD) in Iranian population. Methods: The presence of two CETP gene polymorphisms -629C/A and I405V were studied in 187 unrelated CAD cases and 136 controls. All the samples were clinically examined and lipid profile was estimated. Genotyping was performed using polymerase chain reaction/restriction fragment length polymorphism method. Results: The frequency of -629C/A and I405V allelic variants were found to be 0.732 and 0.366 in cases and 0.658 and 0.348 in controls, respectively. The frequency of A allele of -629C/A polymorphism in cases was significantly higher than that of controls. HDL-C in AA genotype was higher than CA and CC genotypes in controls. No significant effect of II, IV and VV genotypes was found in lipid profiles. Conclusion: No significant association was found between CETP I405V polymorphism and increased risk of CAD in Azeri population studied. AA genotype of -629C/A increased HDL but the risk of CAD in this genotype might be higher than CC genotype. CP - IRAN IN - LG - eng PB - انستیتو-پاستور-ایران PG - 103 PT - Full Length/Original Article YR - 2009