TY - JOUR JF - انستیتو-پاستور-ایران JO - IBJ VL - 7 IS - 4 PY - 2003 Y1 - 2003/10/01 TI - The Effect of Quinapril on the Aortic Contractile Response of Streptozotocin-Diabetic Rats TT - اثر کیناپریل بر پاسخ انقباضی آئورت موش‌های صحرایی دیابتی شده توسط استرپتوزوتوسین N2 - Angiotensin-converting enzyme (ACE) inhibitors appear to correct many of the abnormalities associated with the vascular dysfunction found in diabetic patients. In this respect, quinapril is a unique ACE inhibitor with multiple protective effects. The present study was carried out to investigate the effect of intraperitoneal administration of quinapril on the aortic reactivity of streptozotocin (STZ)-diabetic rats. For this purpose, male Wistar rats received one injection of streptozotocin (STZ), 60 mg/kg, to induce diabetes. Three days after STZ injection, rats were treated with quinapril (2 mg/kg/day) for 4 weeks, after that aortic reactivity to vasoactive agents were compared with those of untreated diabetic rats or non-diabetic control rats. For this purpose, contractile response to phenylephrine (PE) was obtained from aortic rings. Concentration-response curves from quinapril-treated diabetic rats to PE in the presence and absence of endothelium were attenuated as compared to vehicle-treated diabetics. Therefore, the 4-week treatment of diabetic rats with quinapril could prevent the functional changes in vascular reactivity in diabetic rats SP - 173 EP - 177 AU - Roghani Dehkordi, Farshad AU - Roghani, Mehrdad AU - Baluchnejad Mojarad, Tourandokht AD - KW - Quinapril KW - Aortic reactivity KW - Diabetes mellitus KW - STZ KW - Rat UR - http://ibj.pasteur.ac.ir/article-1-525-en.html ER -