AU - Alizadeh, Zohreh AU - Pasbakhsh, Parichehr AU - Sobhani, Aligholi AU - Barbarestani, Mohammad AU - Ghafari, Marefat AU - Etesam, Faride TI - Time Course of Degradation and Deadenylation of Maternal c-mos and Cyclin A2 mRNA during Early Development of One-Cell Embryo in Mouse PT - JOURNAL ARTICLE TA - انستیتو-پاستور-ایران JN - انستیتو-پاستور-ایران VO - 8 VI - 4 IP - 4 4099 - http://ibj.pasteur.ac.ir/article-1-490-en.html 4100 - http://ibj.pasteur.ac.ir/article-1-490-en.pdf SO - انستیتو-پاستور-ایران 4 AB  - Early in the development of many animals, before transcription begins, any change in the pattern of protein synthesis is attributed to a change in the translational activity or stability of mRNA in the egg and early embryo. As a result, translational control is critical for a variety of developmental decisions, including oocyte maturation and initiation of preimplantation development. In this study, using real-time RT-PCR method, we defined the time course of degradation and deadenylation of an oocyte specific gene (c-mos) more precisely and a gene that is re-synthesized after ZGA (cyclin A2). Our data indicate that oocyte-specific transcript, c-mos, degrades rapidly while cyclin A2 mRNA does not and the deadenylation of c-mos mRNA precedes the process of degradation. Our findings suggest that time-dependent elimination of different maternal mRNA is a way for regulation of translation in early development of mouse embryos CP - IRAN IN - LG - eng PB - انستیتو-پاستور-ایران PG - 179 PT - Full Length/Original Article YR - 2004