TY - JOUR JF - انستیتو-پاستور-ایران JO - IBJ VL - 15 IS - 1 PY - 2011 Y1 - 2011/11/01 TI - Human Leukocyte Antigen-G Expression on Dendritic Cells Induced by Transforming Growth Factor-β1 and CD4+ T Cells Proliferation TT - تظاهر HLA-G برروی سلولهای دندریتیک القاء شده توسط TGF-β1 و تکثیر سلولهای C‌D4+ T N2 - Background: During antigen capture and processing, mature dendritic cells (DC) express large amounts of peptide-MHC complexes and accessory molecules on their surface. DC are antigen-presenting cells that have an important role in tolerance and autoimmunity. The transforming growth factor-beta1 (TGF-β1) cytokine has a regulatory role on the immune and non-immune cells. The aim of this study is to evaluate the effect of TGF-β1 on the induction of human leukocyte antigen-G (HLA-G) expression on the DC which is derived from monocyte. Methods: In this study, we evaluated the effect of TGF-β1 in induction HLA-G expression on the monocyte-derived DC by flowcytometry and then CD4+ T cell proliferative responses in the presence of DC-treated TGF-β1 was studied. Results: The results of this study showed that DC bearing HLA-G down-regulated activation of CD4+ T cells and production of IL-6 and IL-17 in comparison with control (P<0.05). Conclusion: It is concluded that TGF-β1 has an important regulatory role in CD4+ T cell proliferation by increasing HLA-G on DC and these cells can probably prevent unexpected immune responses in vivo. SP - 1 EP - 5 AU - Abediankenari, Saeid AU - Ghasemi, Maryam AU - Kim, Young-June AD - KW - Human leukocyte antigen-G (HLA-G) KW - Transforming growth factor-beta1 (TGF-β1) KW - Dendritic cell (DC) KW - IL-17 UR - http://ibj.pasteur.ac.ir/article-1-400-en.html DO - - ER -