Fatemeh Khatami, Seyed Mohammad Tavangar,
Volume 22, Issue 3 (5-2018)
Abstract
Medullary thyroid carcinoma (MTC) is an infrequent calcitonin-producing neuroendocrine tumor that initiates from the parafollicular C cells of the thyroid gland. Several genetic and epigenetic alterations are collaterally responsible for medullary thyroid carcinogenesis. In this review article, we shed light on all the genetic and epigenetic hallmarks of MTC. From the genetic perspective, RET, HRAS, and KRAS are the most important genes that are characterized in MTC. From the epigenetic perspective, Ras-association domain family member 1A, telomerase reverse transcriptase promoter methylations, overexpression of histone methyltransferases, EZH2 and SMYD3, and wide ranging increase and decrease in non-coding RNAs can be responsible for medullary thyroid carcinogenesis.
Zahra Sarostad, Ahmadreza Fallahfaragheh, Zahra Namjou, Mostafa Shokati Ahmad Abad, Hossien Tavangar, Fatemeh Majidpour,
Volume 28, Issue 0 (Supplementary 2024)
Abstract
Introduction: The prevalence of coronary artery disease and its consequences in the country have led to mortality, disability, and a significant portion of the productive workforce being unable to work. Cardiovascular disease has multiple complications for the patient and can affect different aspects of their life. Important variables that are affected are self-efficacy and self-esteem. Patients face a considerable decrease in self-efficacy and self-esteem to overcome and manage their current condition. Therefore, this study was conducted to determine the impact of an educational program on the self-efficacy of patients after coronary artery bypass surgery in the years
2022-2023.
Methods and Materials: This study is a clinical trial. Sixty-nine patients with a history of coronary artery bypass at Afshar Hospital in Yazd were selected using convenience sampling and randomly assigned to two groups: intervention and control. Two 40-minute educational sessions were conducted through practical demonstrations for the intervention group. Data collection tools included demographic questionnaires and self-efficacy scales for cardiac patients, completed before and after the intervention. Data analysis was performed using SPSS version 20 software.
Results: Results showed that the average self-efficacy score in the intervention group significantly increased compared to the control group after the intervention (p = 0.05).
Conclusion and Discussion: The findings of this study indicate that the use of an effective educational program can improve the self-efficacy of patients with a history of coronary artery bypass surgery. Therefore, this relatively accessible and cost-effective intervention can be used to improve patients' health.
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