Showing 3 results for Sanaei
Khadijeh Sanaei, Ali Zamanian, Shohreh Mashayekhan, Tayebe Ramezani,
Volume 27, Issue 5 (9-2023)
Abstract
Background: In the present study, a novel bioink was suggested based on the oxidized alginate (OAlg), gelatin (GL), and silk fibroin (SF) hydrogels.
Methods: The composition of the bioink was optimized by the rheological and printability measurements, and the extrusion-based 3D bioprinting process was performed by applying the optimum OAlg-based bioink.
Results: The results demonstrated that the viscosity of bioink was continuously decreased by increasing the SF/GL ratio, and the bioink displayed a maximum achievable printability (92 ± 2%) at 2% (w/v) of SF and 4% (w/v) of GL. Moreover, the cellular behavior of the scaffolds investigated by MTT assay and live/dead staining confirmed the biocompatibility of the prepared bioink.
Conclusion: The bioprinted OAlg-GL-SF scaffold could have the potential for using in skin tissue engineering applications, which needs further exploration.
Mohanna Yarahmadi, Amir Mohammad Salehi, Elham Khanlarzadeh, Zahra Sanaei, Sahar Mohammadi Mohtasham,
Volume 28, Issue 0 (Supplementary 2024)
Abstract
Introduction: Social capital is one of the main components of socioeconomic development. One definition is the degree of altruism and the level of mutual trust between people in a society. Paying attention to social capital is especially important in higher education because students' access to high social capital can reduce their social and behavioral problems, which also improves the health of the rest of society.
Methods and Materials: This research was a descriptive-analytical study that was conducted among 222 students of Hamedan University of Medical Sciences. In this study, the 36-question Bullen social capital questionnaire was provided to the students in printed form. Data were collected using random and stratified sampling methods and were evaluated with SPSS version 22 software.
Results: The average age of the students was 24 ± 5 years, and in terms of gender, 121 were male and 101 were female. The significant findings of this research indicate that in some areas, the social capital of girls is less than that of boys, married people are less than singles, residents of rented houses are less than residents of private homes and dormitories, and smokers are less than non-smokers. Also, in the field of social participation, working people, and in the field of interactions with family and friends, non-working people had higher social capital. On the other hand, the relationship between age, grade point average, semester, and level of education with social capital was inverse. However, no statistically significant difference in the social capital score was observed in terms of the family's average monthly income. In total, the average social capital score of Hamedan University of Medical Sciences students was 10.835. Conclusion and Discussion: The social capital of students, especially female students, masters, and doctorates, living in rented houses and with a history of alcohol consumption and smoking, is low, so they need more attention and care. In general, employment, celibacy, lower education level, male gender, and living in a dormitory had a positive correlation with the social capital score.
Sina Pakkhesal, Amirreza Naseri, Amir Mohammad Sharafi, Rasa Beheshti, Saman Baharomid, Zahra Koochaki, Fatemeh Amiri, Mahnaz Talebi, Sarvin Sanaei,
Volume 28, Issue 0 (Supplementary 2024)
Abstract
Introduction: Cognitive impairment, as a common symptom of multiple sclerosis (MS), significantly impacts the quality of life of MS patients. In this context, cannabis-based medications (CBMs) have been investigated as a therapeutic option for managing various symptoms of MS, including cognitive dysfunction. Previous systematic reviews provided limited conclusions regarding cognitive outcomes. The present study aimed to provide an updated systematic review and meta-analysis of the existing clinical evidence on the effects of CBMs on cognitive functions in individuals with MS.
Search Strategy: A comprehensive literature search was conducted in May 2024 in major electronic databases, including Web of Science, Embase, Scopus, PubMed, and clinicaltrials.gov, with no time limit. A search strategy based on the terms of randomized-controlled trials (RCTs) evaluating the impact of CBMs on cognitive outcomes/adverse effects in MS patients was considered. Risk-of-bias was assessed using the Cochrane RoB2 tool. Meta-analysis was conducted using Comprehensive Meta-Analysis v3, and a fixed-effects model was used to estimate the pooled effect size. The whole process was according to PRISMA.
Results: From 1,274 primary results, 10 RCTs were included in the qualitative review, and 13 RCTs were included in test-based (331 patients) and event-based (1,232 patients) analyses. The event-based meta-analysis of the attention disturbances showed a significant decline among MS patients receiving CBMs compared to the placebo group (odds-ratio = 2.853, CI 95%: [1.41, 5.77], p = 0.004, I2 = 0.00). The test-based meta-analysis of the Paced Auditory Serial-Addition Test (PASAT) showed a significant difference between CBM and placebo (standardized-mean-difference = 0.387, 95% CI: [0.17, 0.61], p = 0.001, I2=38.87), favoring placebo. Five studies reported no significant effects on processing speed, executive function, and measures of attention and concentration. In contrast, one study observed reduced complex attention and processing speed after acute cannabis administration. Regarding psychomotor skills, three studies indicated impairment. At the same time, the results for multiple domain screenings were mixed, with one study showing a reduction in Short-Orientation-Memory-Concentration Test with THC and another finding no differences between groups.
Conclusion and Discussion: This study suggests that CBM may have adverse effects on attention and processing speed in MS patients; however, overall cognitive impacts of CBM appear to be complex and dependent on factors such as dosage, duration of exposure, and the specific cognitive domains being assessed.
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