Showing 7 results for Nasiri
Shohreh Farshad, Abdolvahab Alborzi, Aziz Japoni, Masoumeh Hayati, Mehdi Saberfirouzi, Kamran Bagheri Lankarani, Alireza Taghavi, Jalil Nasiri, Noreddin Rafatpour,
Volume 10, Issue 2 (4-2006)
Abstract
It is not clear what factors determine divergent outcomes of infections caused by H. pylori . In the present study, the protein profiles of different strains of H. pylori, isolated from three groups of patients with ulcerative disease, non-ulcerative gastritis and cancer disease, were analyzed using 1DSDS-PAGE. The patterns of different H. pylori strains were highly divergent. About 30.76% (7 bands) of the 26 observed protein bands were common in all strains isolated from 3 groups of the patients. While the similarity for the strains inside each group were 75% (15 from 20), 76.47% (13 from 17) and 78.57% (11 from 14) for cancerous, ulcerative and nonulcerative group, respectively. Some of the observed bands were significantly specific for each group. Therefore, we speculated that some H. pylori strains might be more associated with a specific disease than others, giving the clustering of some, but not all, strains within each disease group. In conclusion, this study showed that protein profile can be a characteristic in discrimination of dominant strains in different gastric clinical status. Specific and dominant proteins of different strains isolated from three groups of patients under study were candidates for further exploration for laboratory tests, which analyze disease-specific H. pylori strains, and for diagnosis of the different diseases and outcomes associated with this widespread bacterium.
Fatemeh Gharishvandi, Faranak Kazerouni, Esmat Ghanei, Ali Rahimipour, Malihe Nasiri,
Volume 19, Issue 2 (4-2015)
Abstract
Background: Hypertension is one the most common causes of chronic kidney disease (CKD). One of the major concerns in hypertensive patients is early detection of renal disorders. In the past, serum creatinine (Scr) concentration was used as a marker of kidney function, but it proffers a late reflection of reduced glomerular filtration rate. Cystatin C and neutrophil gelatinase-associated lipocalin (NGAL) have been recently proven to be useful for quantification of CKD. Therefore, we compared the diagnostic value of NGAL with cystatin C and creatinine to evaluate kidney function in hypertensive patients. Methods: In this study, 42 hypertensive patients and 30 healthy volunteers were recruited. Serum cystatin C (Scys C) and plasma NGAL were measured using ELISA method. Creatinine, urea, hemoglobin, fibrinogen, and C-reactive protein were measured according to the routine methods. Estimated glomerular filtration rate (eGFR) was considered as the gold standard method (cut-off value of < 78 ml/min/1.73 m2. Results: In the patient group, plasma NGAL, cystatin C, and creatinine were all significantly correlated with eGFR, and plasma NGAL correlated best with eGFR. Receiver-operating characteristics analysis indicated that plasma NGAL was a better indicator than creatinine and cystatin C for predicting a GFR < 78 ml.min.1.73 m2. The sensitivity and specificity for NGAL were 96% and 100%, for cystatin C were 92% and 60% and for creatinine were 76% and 47%, respectively. Conclusion: Plasma NGAL demonstrated a higher diagnostic value to detect kidney impairment in the early stages of CKD as compared to Scys C and Scr in hypertensive patients.
Fatemeh Amiri, Sedigheh Molaei, Marzie Bahadori, Fatemeh Nasiri, Mohammad Reza Deyhim, Mohammad Ali Jalili, Mohammad Reza Nourani, Mehryar Habibi Roudkenar,
Volume 20, Issue 3 (7-2016)
Abstract
Background: Mesenchymal stem cells (MSCs) have been recently received increasing attention for cell-based therapy, especially in regenerative medicine. However, the low survival rate of these cells restricts their therapeutic applications. It is hypothesized that autophagy might play an important role in cellular homeostasis and survival. This study aims to investigate the regenerative potentials of autophagy-modulated MSCs for the treatment of acute liver failure (ALF) in mice. Methods: ALF was induced in mice by intraperitoneal injection of 1.5 ml/kg carbon tetrachloride. Mice were intravenously infused with MSCs, which were suppressed in their autophagy pathway. Blood and liver samples were collected at different intervals (24, 48 and 72 h) after the transplantation of MSCs. Both the liver enzymes and tissue necrosis levels were evaluated using biochemical and histopathological assessments. The survival rate of the transplanted mice was also recorded during one week. Results: Biochemical and pathological results indicated that 1.5 ml/kg carbon tetrachloride induces ALF in mice. A significant reduction of liver enzymes and necrosis score were observed in autophagy-modulated MSC-transplanted mice compared to sham (with no cell therapy) after 24 h. After 72 h, liver enzymes reached their normal levels in mice transplanted with autophagy-suppressed MSCs. Interestingly, normal histology without necrosis was also observed. Conclusion: Autophagy suppression in MSCs ameliorates their liver regeneration potentials due to paracrine effects and might be suggested as a new strategy for the improvement of cell therapy in ALF.
Ali Moradi, Akram Sanagoo, Ali Akbari, Anita Gharajeh, Zahra Talebi, Leila Jouybari, Hossein Nasiri, Fatemeh Mehravar,
Volume 28, Issue 0 (Supplementary 2024)
Abstract
Introduction: Creating age-friendly cities and spaces is one of the fundamental challenges in today's world. This study aims to evaluate age-friendly city indicators from the perspective of the elderly in Golestan Province in 2023.
Methods and Materials: This descriptive-analytical cross-sectional study was conducted on individuals aged 60 and above in the counties of Golestan Province. The sample size was 310 participants selected through proportional stratified sampling. Data were collected using the age-friendly city questionnaire, which was validated and reliable for the Iranian population. The collected data were analyzed using SPSS version 26, employing independent t-test, analysis of variance (ANOVA), chi-square, and Pearson correlation.
Results: The mean age of the participants in this study was 70.34 ± 7.73 years (ranging from 60 to 99), with 64.5% being male. Among the three examined components, respect, and social security had the highest average among the elderly (4.65 ± 17.72), followed by social participation (4.79 ± 16.30) and civic engagement and employment (4.052 ± 12.20). Age-friendly city indicators showed statistically significant differences in variables such as city of residence (p = 0.02), support source (p = 0.009), income level (p = 0.001), and marital status (p = 0.05).
Conclusion and Discussion: The findings of this study indicated that none of the three examined components of age-friendly city indicators in Golestan Province met the necessary standards. Therefore, it is recommended that managers of organizations responsible for the elderly exert more effort to achieve desirable conditions.
Amirhosein Nasirmoghadas, Fariba Borhani, Fatemeh Monjazebi, Maliheh Nasiri, Aydin Feyzi,
Volume 28, Issue 0 (Supplementary 2024)
Abstract
Introduction: Heart failure (HF) is the most common cardiovascular reason for hospitalization of patients over 60 years old. Fatigue and dyspnea are the main symptoms of HF and cause deterioration of patients' daily function and self-care. This study aimed to determine the effectiveness of breathing exercises using two methods on fatigue severity, dyspnea, and the New York Heart Association (NYHA) functional classification in these patients.
Methods and Materials: This three-arm clinical trial was conducted on 90 adult HF patients. Participants were randomly assigned to three groups (30 participants in each group), including diaphragmatic and pursed-lip breathing (DG), flow-oriented incentive spirometry (SG), and a control group (CG). The interventions were performed three times daily for 10 days in DG and SG. While participating in this study, none of the patients were deprived of continuing the treatment and care procedures prescribed by the medical staff. Before and after the intervention, data were collected using the Fatigue Severity Scale (FSS), modified Borg dyspnea scale (at rest and during activity), and NYHA functional classification. The data analysis of the study was perfumed using SPSS-20 software.
Results: There was no significant difference between the three groups regarding baseline characteristics. Fatigue severity in the two intervention groups significantly decreased (p = 0.001). The frequency of patients with severe fatigue decreased by 30% in both DG and SG. The mean dyspnea score in DG and SG decreased by 0.7 and 0.9 units at rest (p = 0.001) and decreased by 2.93 and 2.73 units during activity (p = 0.001). Regarding NYHA functional classification, the frequency of patients in classes III and IV was significantly decreased by 30% in DG and 33.3% in SG (p = 0.001). However, after the intervention, there was no significant difference between DG and SG regarding improvement and reduction in fatigue severity, dyspnea, and NYHA functional classification. None of these items were statistically different in CG before or after the intervention.
Conclusion and Discussion: The present study show that breathing exercises using two methods, diaphragmatic and pursed-lip breathing exercises, and flow-oriented incentive spirometry, reduce fatigue and dyspnea and improve NYHA functional classification of patients with HF. Also, breathing exercises should be included in the nursing care program for HF patients as a simple, low-cost, and uncomplicated intervention.
Mehrad Amirnia, Khazar Raeisnia, Hamidreza Ashayeri, Zahra Hakimzadeh, Ehsan Nasiri, Mahnaz Talebi, Sarvin Sanaie, Amirreza Naseri,
Volume 28, Issue 0 (Supplementary 2024)
Abstract
Introduction: Multiple sclerosis (MS) is an immune-mediated disease with several etiological origins. Caffeine is an adenosine receptor antagonist in the central nervous and immune systems. Due to the pharmacologic properties of caffeine, it has neuroprotective and anti-inflammatory features. These propose a potential influence on MS risk, but the studies investigating the effect of coffee on MS development show conflicting results. This study aimed to assess existing clinical evidence on the association between caffeine consumption and the risk of MS.
Search Strategy: A comprehensive search was conducted in databases, including PubMed, Scopus, Web of Science, and Embase, to cover all articles published up to January 2024 using the following strategy for PubMed: ("Coffee" [Mesh] OR "Caffeine" [Mesh] OR Coffee OR Caffeine OR Vivarin OR Caffedrine OR Coffeinum) AND ("Multiple Sclerosis" [Mesh] OR "Multiple sclerosis"). No restriction on search date, language, or country of origin was applied during the search. Also, the reference lists and citations of the included studies and related review articles were checked.
Results: Among 604 initial records, 10 studies (eight case-control studies, one cohort, and one Mendelian randomized study) with 19,430 participants met the inclusion criteria. The included case-control studies showed an overall high quality (4 scored 100% and 4 scored 90%). Our meta-analysis showed reduced MS development in coffee consumers (OR: 0.66). The protective effects of coffee were also higher in the groups consuming at least three cups daily compared to those consuming less than three cups (OR: 0.83).
Conclusion and Discussion: The current evidence on the impact of caffeine on MS risk is inconclusive, with studies showing both protective and neutral effects. Coffee consumption, especially in high doses, may decrease the risk of MS; however, the variability in outcomes highlights the influence of study design, demographic factors, and methodological approaches in assessing dietary impacts on disease incidence. Further well-designed prospective studies are required to clarify the role of caffeine in MS pathophysiology and to explore potential protective or predisposing effects on its incidence.
Minoo Sabetnejad, Alireza Iraj, Mina Nasiri, Zahra Behboodi Moghadam,
Volume 28, Issue 0 (Supplementary 2024)
Abstract
Introduction: Episiotomy is a standard surgical procedure performed during labor to widen the vaginal opening, and it can lead to pain, anxiety, and fear in mothers. Virtual reality (VR) interventions have emerged as a potential tool to alleviate pain and anxiety in various medical settings. This systematic review aims to evaluate the effects of VR interventions on maternal experience during episiotomy procedures in labor.
Search Strategy: This study followed Cochrane systematic review principles and PRISMA guidelines, searching various scientific databases, including PubMed, Web of Science, Scopus, and the Google Scholar search engine for grey literature. The search was conducted without time limitations, using keywords “virtual reality”, “episiotomy”, “episiotomies”, and their related synonyms. Inclusion criteria encompassed randomized controlled trials aiming to assess the effectiveness of VR interventions in women experiencing episiotomy compared to controlled ones. Exclusion criteria included duplicate publications, reviews, observational and quasi-experimental studies, book chapters, letters to the editor, and studies lacking primary data or clear method descriptions. Two authors conducted screening and data extraction independently, and any disagreements were resolved through consensus involving a third author. The ROB2 critical appraisal tool was used to assess the quality of the included articles, and the final data was presented in an extraction table.
Results: A total of 33 articles were initially identified, with 13 duplicates and 12 irrelevant titles. Finally, eight studies were included. Significant differences between intervention and control groups were observed in several key outcomes, including reduced anxiety (n = 2) and reduced pain during and after episiotomy (n = 5). They Increased satisfaction with using VR devices
(n = 3). However, two studies reported no significant impact of VR on anxiety.
Conclusion and Discussion: The findings suggest that VR interventions may contribute to reduced anxiety, decreased pain, and increased satisfaction among mothers undergoing episiotomy. These results underscore the value of exploring non-pharmacological interventions, such as virtual reality, to enhance maternal care and well-being during labor and delivery. Further research is warranted to elucidate the optimal design and implementation of VR interventions in this context and to address the variability in outcomes observed across studies.
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