Showing 2 results for Kourosh Arami
Massoomeh Kourosh Arami, Abdolrahman Sarihi, Seyed Mansour Malacoti, Gila Behzadi, Mehrangiz Vahabian, Iraj Amiri,
Volume 10, Issue 1 (1-2006)
Abstract
It has been shown that nitric oxide is synthesized in the central nervous system as well as in vascular endothelial cells. Recently, it was reported that nitric oxide was involved in central cardiovascular regulation, baroreflex modulation, and involved in a reciprocal release with excitatory amino acids in the nucleus tractus solitarii of rats. The purpose of the present study was to investigate the possible interaction of nitric oxide and glucose in the nucleus tractus solitarii on blood pressure regulation. Male Wistar stereptozotocin induced diabetic rats were anesthetized with urethane. A cannula was inserted above the nucleus tractus solitarii and blood pressure was monitored intra-arterially. Unilateral microinjection of L-glutamate (2.3 nmol/60 nL) into the nucleus produced a decrease in blood pressure in diabetic rats. Microinjection of lidocaine (0.5 µl %2) increased blood pressure. Unilateral microinjection of sodium nitroprusside (100 mmol/60 nL) into the nucleus increased blood pressure in diabetic rats. After microinjection of sodium nitroprusside, the depressive responses to glutamate were significantly attenuated. These results demonstrated the probable role of glucose on blood pressure regulation in diabetic animals affecting on nitric oxidergic neurons and so it implicates an interaction between nitric oxide and glucose in central cardiovascular regulation. Iran. Biomed. J. 10 (1): 15-19, 2006
Seyed Mansour Malakouti, Masoomeh Kourosh Arami, Abdorahman Sarihi, Sohrab Hajizadeh, Gila Behzadi, Siamak Shahidi, Alireza Komaki, Behnam Heshmatian, Mehrangiz Vahabian,
Volume 12, Issue 4 (10-2008)
Abstract
Background: The nucleus raphe magnus (NRM) is involved in thermoregulatory processing. There is a correlation between changes in the firing rates of the cells in the NRM and the application of the peripheral thermal stimulus. Introduction: we examined the effect of reversible inactivation and excitation of NRM on mechanisms involved in tail blood flow (TBF) regulation in hypothermia. Methods: Hypothermia was induced in Male Wistar rats and cannula was implanted above the NRM. To evaluate the effect of nucleus inactivation on TBF, the amount of TBF was measured by Laser Doppler in hypothermic rats, before and after lidocaine microinjection into NRM. TBF was also measured after glutamate microinjection to assess the effect of nucleus excitation in hypothermic rats. Results: Results indicated that after dropping TBF by hypothermia, microinjection of lidocaine into NRM significantly decreased TBF from 54.43 ± 5.7 to 46.81 ± 3.4, whereas glutamate microinjection caused a significant increase from 44.194 ± 0.6 to 98 ± 10.0. Conclusion: These data suggest that NRM have thermoregulatory effect in response to hypothermia.
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