Mohammad-Nazir Menbari, Karim Rahimi, Abbas Ahmadi, Samira Mohammadi-Yeganeh, Anvar Elyasi, Nikoo Darvishi, Vahedeh Hosseini, Mohammad Abdi,
Volume 24, Issue 5 (9-2020)
Abstract
Background: Previous data have shown the tumorigenicity roles of histone deacetylase 8 (HDAC 8) in breast cancer. More recently, the oncogenic effects of this molecule have been revealed in triple negative breast cancer (TNBC). The present study aimed to determine the diagnostic value of HDAC8 for the differentiation of TNBC from nTNBC tumors. Methods: A total of 50 cancerous and normal adjacent tumor specimens were obtained, and the clinical and pathological findings of studied subjects were recorded. The expression of HDAC8 gene was determined by qRT-PCR. Also, immunohistochemical staining was performed on tissue samples. Results: Our results showed that the expression of HDAC8 in breast cancer tissues was significantly higher than the normal adjacent tissues (p = 0.0011). HDAC8 expression was also observed to be higher in TNBC patients than nTNBC group (p = 0.0013). In addition, in the TNBC group, there was a significant association between the HDAC8 overexpression and tumor characteristics, including tumor size (p = 0.039), lymphatic invasion (p = 0.01), tumor grade (p = 0.02), and perineural invasion (p < 0.05). The cut-off value was fixed at 0.6279 r.u., and the corresponding sensitivity and specificity were found to be 73.91% and 70.37%, respectively. Conclusion: According to the findings, among the other markers, HDAC8 oncogene may be used as a potential tumor marker in the diagnosis of TNBC tumors.
Asma Darvishi, Fatemeh Zarimeidani, Nikoo Almani, Hossein Keyhani, Rahem Rahmati, Hadi Raeisi Shahraki,
Volume 28, Issue 0 (Supplementary 2024)
Abstract
Introduction: According to several studies, 20-45% of college students encounter at least one mental health condition in any one year, and mental diseases are becoming more prevalent in colleges worldwide. Understanding the relationship between alexithymia and depression, anxiety, and stress among university students can provide valuable insights into mental health challenges faced by this population. Addressing alexithymia with these co-occurring conditions can lead to more effective intervention strategies and support services. This study evaluated the mental health challenges of medical university students.
Methods and Materials: A total of 260 students from the 2019-2020 academic year at Shahrekord University of Medical Sciences were selected using a multi-stage cluster sampling method . To assess alexithymia and depression, stress, and anxiety, standardized questionnaires, specifically the Depression Anxiety Stress Scale-21 and the Toronto Alexithymia Scale, were employed. To compare the scores of depression, stress, and anxiety between students with and without alexithymia, an independent t-test using SPSS 21.0 software was conducted. Additionally, the logistic regression model was utilized to examine the adjusted associations.
Results: Among 260 students, the majority were female (75.7%) and most students aged 20. The study found that male students had a higher mean alexithymia score compared to female students (55.4 ± 12.6 versus 51.6 ± 12.5; p = 0.04), while younger students aged 18-19 exhibited lower mean scores for depression and anxiety compared to older students (4.3 ± 3.2 versus 5.3 ± 3.8 for thosed aged 20; p = 0.04). Similarly, the mean anxiety score was lower in younger students (5.6 ± 4.5 versus 6.9 ± 5.1; p = 0.04). Other demographic factors such as marital status, ethnicity, and residence did not significantly impact these mental health indicators. Pearson correlation analysis revealed significant positive correlations between alexithymia, stress, depression, and anxiety, with depression also being significantly correlated with anxiety and stress and anxiety being significantly correlated with stress.
Conclusion and Discussion: Given the strong correlations between alexithymia and depression, anxiety, and stress, and the potential for exacerbation of each other, it is important to assess students for these disorders. Additional research is necessary for a comprehensive understanding of this topic.
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