Showing 3 results for Baghban
Mohammadreza Galegirian, Niloofar Dehghan, Mehdi Khaleghi, Neda Baghban,
Volume 28, Issue 0 (Supplementary 2024)
Abstract
Introduction: Phycocyanin (PC), a light-harvesting protein complex derived from micro-algae such as Spirulina platensis, has been recognized for its therapeutic properties, including antioxidant, anti-inflammatory, and wound-healing capabilities. This systematic review summarized available knowledge on extracting PC from spirulina and its potential in skin wound healing.
Search Strategy: Following the PRISMA guidelines, a systematic search was conducted in databases including PubMed, Scopus, Web of Science, and Embase using the keywords "phycocyanin" and "wound healing" or "wound repair" or "biomedical applications" or "tissue regeneration"] in the title, abstract, and keywords. The search was limited to studies published in English from 2004 to 2023.
Results: A total of 59 studies were included. The review encompassed in vitro, in vivo, and clinical studies exploring PC's effects on skin wound healing. PC, particularly C-phycocyanin (C-PC) from Spirulina, was found to promote fibroblast proliferation and urokinase-type plasminogen activator (uPA) migration, inducing the G1 phase of the cell cycle and increasing the expression of cyclin-dependent kinases (cdK1 and cdK2). In vivo studies in mice demonstrated that C-PC treatment resulted in an 80% closure of wounds by the end of the first week, compared to 50% closure in control groups. Additionally, C-PC was shown to regulate uPA gene expression via a cAMP-mediated mechanism dependent on the PKA pathway.
Conclusion and Discussion: Evidence synthesized in this review underscores the potential of PC, particularly C-PC from Spirulina, as an active component in medicinal products for wound treatment. Its ability to enhance cell proliferation and migration suggests its utility in healing external and internal wounds, such as ulcers. However, further research is needed to optimize its therapeutic use and establish standardized protocols for PC extraction and application in wound care.
Tuba Zendehboudi, Neda Baghban,
Volume 28, Issue 0 (Supplementary 2024)
Abstract
Introduction: Magnetic nanoparticles (MNPs) have gained considerable attention as drug delivery vehicles due to their unique magnetic properties and high surface area. Antibody-conjugated MNPs have been developed as a targeted drug delivery system, enabling the specific delivery of drugs to target cells or tissues. This systematic review aimed to evaluate the current knowledge on the application of antibody-conjugated MNPs in drug delivery, including their synthesis, characterization, and efficacy in vitro and in vivo.
Search Study: A comprehensive literature search was conducted using the PubMed database. The search strategy included the keywords “delivery[Title/Abstract]” AND “antibody[Title/Abstract]” AND “magnetic[Title/Abstract]” OR “iron[Title/Abstract]”. Only studies published between 2020 and 2023 were included in the review.
Results: A total of 84 studies were included in this review. The studies investigated the synthesis, characterization, and efficacy of antibody-conjugated MNPs in drug delivery for various diseases, including cancer, cardiovascular diseases, and infectious diseases. The results showed that antibody-conjugated MNPs can enhance the specificity and efficacy of drug delivery by targeting specific cells or tissues. Moreover, the physicochemical properties of MNPs, such as size, shape, and surface charge, can affect their efficacy in drug delivery. Several in vitro and in vivo studies have demonstrated the potential of antibody-conjugated MNPs in targeted drug delivery, with promising results.
Conclusion and Discussion: The findings of this systematic review suggest that antibody-conjugated MNPs have potential as a targeted drug delivery system for various diseases. The physicochemical properties of MNPs and the choice of antibody and drug can affect the efficacy of drug delivery. However, further research is needed to optimize the synthesis and characterization of antibody-conjugated MNPs, to evaluate their safety and efficacy in human clinical trials, and to explore their potential combination with other drug delivery systems.
Zohreh Farrar, Neda Baghban, Robab Bahreini,
Volume 28, Issue 0 (Supplementary 2024)
Abstract
Introduction: The field of tissue engineering has been revolutionized by the advent of innovative scaffolds, which integrate advanced biomaterials and technologies to facilitate complex tissue reconstruction. These scaffolds mimic the natural extracellular matrix, promote cellular interactions, and support tissue regeneration. This systematic review aims to evaluate the current state of innovative scaffolds in complex tissue reconstruction, highlighting their design, functionality, and clinical applications.
Search Strategy: A comprehensive literature search was conducted across multiple databases, including PubMed, Scopus, and Google Scholar, for articles published from 2000 to 2023. Keywords used in the search in title, keywords, and abstract included ["smart scaffolds" or "biomaterials" or “3D printing”] and ["tissue engineering" or tissue reconstruction" or "regenerative medicine" or "tissue repair"]. Inclusion criteria comprised original research articles, reviews, and clinical studies that discussed innovative scaffold development, characterization, and application. Exclusion criteria included studies not in English, conference abstracts, and articles without full-text availability.
Results: The search yielded 1,256 articles, of which 102 met the inclusion criteria. The review identified various innovative scaffold materials, including natural polymers (e.g., collagen, chitosan), synthetic polymers (e.g., PLGA, PEG), and hybrid composites. Advanced fabrication techniques such as 3D printing, electrospinning, and bioprinting were frequently employed. Key functionalities of innovative scaffolds included controlled drug delivery, stimuli-responsive properties, and the incorporation of growth factors. Clinical applications spanned a range of tissues, including bone, cartilage, skin, and neural tissues. The results indicated that innovative scaffolds significantly enhance tissue regeneration, with several studies demonstrating improved outcomes in preclinical and clinical settings.
Conclusion and Discussion: Smart scaffolds represent a promising approach for complex tissue reconstruction, offering tailored structural and functional properties that facilitate tissue regeneration. This systematic review underscores the importance of interdisciplinary collaboration in advancing scaffold design and application. Future research should focus on optimizing scaffold properties, understanding long-term biocompatibility, and conducting large-scale clinical trials to validate efficacy. The integration of emerging technologies, such as bioprinting and nanotechnology, is anticipated to further enhance the capabilities of innovative scaffolds in regenerative medicine.
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