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The Role of High-Fructose Diet in Liver Function of Rodent Models: A Systematic Review of Molecular Analysis
Roya Mirzaei, Roya Khosrokhavar, Sepideh Arbabi Bidgoli,
Volume 27, Issue 6 (11-2023)
Abstract
The present systematic review of animal studies on long-term fructose intake in rodents revealed a significant decrease in the activities of antioxidant enzymes due to a fructose-rich diet. The reduced activity of these enzymes led to an increase in oxidative stress, which can cause liver damage in rodents. Of eight studies analyzed, 5 (62.5%) and 1 (12.5%) used male and female rats, respectively, while 2 studies (25%) used female mice. Moreover, half of the studies used high-fructose corn syrup, but the other half employed fructose in the diet. Hence, it is essential to monitor dietary habits to ensure public health and nutrition research outcomes.
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