Volume 17, Issue 2 (4-2013)                   ibj 2013, 17(2): 107-111 | Back to browse issues page

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Carvalho de M. Thiele M, Carlos Bohn C B, Lima Chaiben C, Trindade Grégio A M, Ângela Naval Machado M, Adilson Soares de Lima A. Nucleolar Organizer Regions of Oral Epithelial Cells in Crack Cocaine Users. ibj. 2013; 17 (2) :107-111
URL: http://ibj.pasteur.ac.ir/article-1-934-en.html

Background: The health risks of crack cocaine smoking on the oral mucosa has not been widely researched and documented. Objective: The purpose of this study was to analyze the proliferative activity of oral epithelial cells exposed to crack cocaine smoke using silver nucleolar organizer region (AgNOR) staining. Methods: Oral smears were collected from clinically normal-appearing buccal mucosa by liquid-based exfoliative cytology of 60 individuals (30 crack cocaine users and 30 healthy controls matched for age and gender) and analyzed for cytomorphologic and cytomorphometric techniques. Results: Crack cocaine users consumed about 13.3 heat-stable rocks per day and the time consumption of the drug was of 5.2 (± 3.3) years. Mean values of AgNOR counting for case and control groups were 5.18 ± 1.83 and 3.38 ± 1.02 (P<0.05), respectively. AgNOR area and percentage of AgNOR-occupied nuclear area were increased in comparison with the control (P<0.05). There was no statistically significant difference in the mean values of the nuclear area between the groups (P>0.05). Conclusion: This study revealed that crack cocaine smoke increases the rate of cellular proliferation in cells of normal buccal mucosa.

Type of Study: Short Communication | Subject: Related Fields

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