Volume 1, Issue 4 (10-1997)                   IBJ 1997, 1(4): 1-9 | Back to browse issues page

‎ 20.1001.1.1028852.1997.1.4.4.6

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Functional and Physical Consequence of Human Immunodefficiency Virus Transactivator TAT Interaction with Human Cell Cycle Regulator p53
Janet Duvall , Fatah Kashanchi
Abstract:  
Human immunodeficiency virus (HIV) transactivator Tat is a potent activator of both viral and cellu‌lar genes. Tat has also been implicated in the development of AIDS-related malignancy. Here, we show that Tat physically and functionally is able to sequester the cell cycle check point protein p53. This sequestration results in non-functional promoter activity of cyclin-dependent kinase/cyclin in‌hibitor, namely p21 (Waf1). Therefore, it is proposed that a Tat/p53 complex in vivo may deregulate p53 responsive genes, hence allowing for deregulation of check point, which may lead to development of malignancies.
Keywords: HIV, TAT, Transcription, Cell cycle, p53
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Type of Study: Full Length/Original Article |
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