Iranian
Biomedical Journal
Volume 3, Issue 1 And 2 (1-1999)
IBJ 1999, 3(1 And 2): 47-51 |
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Yazdanparast R, Qujeq D. Significant Changes in the Activity of L-Glutamic Acid Decarboxylase of Mouse Hypothalamus After Peripheral Injection of Cholecystokinin-8 and Caerulein. IBJ 1999; 3 (1 and 2) :47-51
URL: http://ibj.pasteur.ac.ir/article-1-857-en.html
URL: http://ibj.pasteur.ac.ir/article-1-857-en.html
Abstract:
The activity of one of the metabolizing enzymes of - aminobutyric acid, (GABA), was determined in mouse hypothalamus after peripheral injections of cholecystokinin-8 (CCK-8) and caerulein (CLN). The activity of this rate-limiting enzyme, L-glutamic acid decarboxylase, (GAD), did not change thirty minutes after peripheral injections of either CCK-8 or CLN in doses of 50g/kg body weight. However, the activity of GAD started to increase 24 hours after injection and continued to increase by 15 to 17%, five days after injections. Based on the in vitro models, it has been shown that there are no direct interactions between CCK-8 and CLN and the enzyme GAD. These data probably support indirect but specific interactions between CCK-8, CLN and the enzyme GAD.
Type of Study: Full Length/Original Article |
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