:: Volume 5, Issue 2 And 3 (3-2001) ::
IBJ 2001, 5(2 And 3): 87-95 Back to browse issues page
Synthesis and Application of New Gadolinium-Porphyrins as Potential MR Imaging Contrast Agents for Cancer Detection in Nude Mice
Daryoush Shahbazi-Gahrouei , Mark Williams , Barry J. Allen
Abstract:  
Two new potential magnetic resonance imaging contrast agents, Gd-hematoporphyrin (Gd-H) and Gd-tetra-carboranylmethoxyphenyl-porphyrin (Gd TCP), were synthesized and applied to nude mice with human melanoma (MM 138) xenografts. These agents showed a high relaxivity because of their greater potential to coordinate water molecules. The reduction of T1 relaxation times of 16 and 21% was observed in human melanoma tumors grafted in the nude mice 24 h after injection of Gd-TCP and Gd-H, respectively. The percent of injected Gd, that localized to the tumor and measured by inductively coupled plasma atomic emission spectroscopy (ICP-AES), was approximately 21% for Gd-TCP and 28% for Gd-H. A higher concentration of Gd was achieved compared with control indicating selective delivery of Gd-porphyrins to the melanoma xenografts. The data indicate that Gd-TCP can be used as a dual probe for diagnosis in MR imaging and for therapy in boron neutron capture therapy (BNCT).
Keywords: MR imaging, Contrast agent, Porphyrins, Melanoma, Cancer
Full-Text [PDF 136 kb]      
Type of Study: Full Length |
Send email to the article author

Add your comments about this article
Your username or Email:

Write the security code in the box >


XML     Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Shahbazi-Gahrouei D, Williams M, Allen B J. Synthesis and Application of New Gadolinium-Porphyrins as Potential MR Imaging Contrast Agents for Cancer Detection in Nude Mice. IBJ. 2001; 5 (2 and 3) :87-95
URL: http://ibj.pasteur.ac.ir/article-1-639-en.html


Volume 5, Issue 2 And 3 (3-2001) Back to browse issues page
Persian site map - English site map - Created in 0.19 seconds with 37 queries by YEKTAWEB 3647