:: Volume 5, Issue 2 And 3 (3-2001) ::
IBJ 2001, 5(2 And 3): 55-59 Back to browse issues page
Up-Regulation of Integrinsn α2β1 and α3β1 Expression in Human Foreskin Fibroblast Cells after In-Vitro Infection with Herpes Simplex Virus Type 1
Shapour Shahgasempour , Ali Shamsi Shahomabadi , Farah-Dokht Fateminasab , Abbas Barin
Abstract:  
The interaction of Herpes Simplex Virus type 1 (HSV-1) with human fetal foreskin fibroblast (HFFF) cell was studied using a recent isolate of HSV-1 which was propagated in Hep-2 cells. HFFF cells were challenged with HSV-1 with a multiplicity of infection (MOI) of 1 virus/cell for 24 hours. Flow cytometric analysis demonstrated that HSV-1 challenged HFFF cells expressed increased levels of α2β1, α3β1 (a collagen and laminin receptor) and LFA-1 (a β2 integrin, ligand for intercellular adhesion molecule-1, ICAM-1) integrins without a significant change in the expression of α5b1 (a fibronectin receptor) as compared to the mock-challenged cells. In addition, virus challenged HFFF cells showed increased expression of ICAM-1 and HLA class I antigen when compared to mock-infected cells. These results suggest that HSV-1 is capable of inducing functional changes in human foreskin fibroblast cells. The altered expression of cell-matrix and cell-cell adhesion molecules resulting from HSV-1 infection could contribute to the immunopathological diseases associated with HSV-1 infection in vivo.
Keywords: Fibroblasts, HSV-1, Integrin receptors, Adhesion molecules
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Shahgasempour S, Shamsi Shahomabadi A, Fateminasab F, Barin A. Up-Regulation of Integrinsn α2β1 and α3β1 Expression in Human Foreskin Fibroblast Cells after In-Vitro Infection with Herpes Simplex Virus Type 1. IBJ. 2001; 5 (2 and 3) :55-59
URL: http://ibj.pasteur.ac.ir/article-1-638-en.html


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