:: Volume 5, Issue 2 And 3 (3-2001) ::
IBJ 2001, 5(2 And 3): 103-106 Back to browse issues page
Hormone-Induced Variation of Phosphatidate Phosphohydrolase Activity in Various Tissues of Pregnant Rats
Bahram Haghighi , Mahboobeh Farsadi
Abstract:  

Variations in phosphatidate phosphohydrolase (PAP) activity and triacylglycerol concentration were measured in pregnant and hormone-treated non-pregnant female rats. PAP activity in adipose tissue was elevated by 61% during pregnancy. The increase in the enzyme activity was paralleled with a rise in serum triacylglycerol concentration (44%). Estradiol injecting into non-pregnant rats increased PAP activity of both adipose tissue (19.8%) and the liver (26%). Progesterone also elevated the enzyme activities of adipose tissue and liver by 10% and 55%, respectively. Both hormones increased serum triacylglycerol concentration (20-29%). The data demonstrated that hypertriglyceridemia observed during pregnancy was mediated through the hormonal effects on PAP activity, a key enzyme in glycerolipid metabolism.

Keywords: Phosphohydrolase, Hyperlipidemia, Pregnancy
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Type of Study: Short Communication |
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Haghighi B, Farsadi M. Hormone-Induced Variation of Phosphatidate Phosphohydrolase Activity in Various Tissues of Pregnant Rats. IBJ. 2001; 5 (2 and 3) :103-106
URL: http://ibj.pasteur.ac.ir/article-1-633-en.html


Volume 5, Issue 2 And 3 (3-2001) Back to browse issues page
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