Iranian
Biomedical Journal
Volume 13, Issue 2 (4-2009)
IBJ 2009, 13(2): 103-108 |
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Ghatreh Samani K, Noori M, Rohbani Nobar M, Hashemzadeh Chaleshtori M, Farrokhi E, Darabi Amin M. I405V and -629C/A Polymorphisms of the Cholesteryl Ester Transfer Protein Gene in Patients with Coronary Artery Disease. IBJ 2009; 13 (2) :103-108
URL: http://ibj.pasteur.ac.ir/article-1-62-en.html
URL: http://ibj.pasteur.ac.ir/article-1-62-en.html
Keihan Ghatreh Samani 
, Mohammad Noori , Mohammad Rohbani Nobar , Morteza Hashemzadeh Chaleshtori , Effat Farrokhi , Masoud Darabi Amin
, Mohammad Noori , Mohammad Rohbani Nobar , Morteza Hashemzadeh Chaleshtori , Effat Farrokhi , Masoud Darabi Amin
Abstract:
Background: Cholesteryl ester transfer protein (CETP) plays a main role in high-density lipoprotein metabolism. CETP gene possesses several single nucleotide polymorphisms which have been associated with plasma high-density lipoprotein cholesterol (HDL-C) concentrations. The aim of this study was to determine the association of CETP -629C/A and I405V polymorphisms with coronary artery disease (CAD) in Iranian population. Methods: The presence of two CETP gene polymorphisms -629C/A and I405V were studied in 187 unrelated CAD cases and 136 controls. All the samples were clinically examined and lipid profile was estimated. Genotyping was performed using polymerase chain reaction/restriction fragment length polymorphism method. Results: The frequency of -629C/A and I405V allelic variants were found to be 0.732 and 0.366 in cases and 0.658 and 0.348 in controls, respectively. The frequency of A allele of -629C/A polymorphism in cases was significantly higher than that of controls. HDL-C in AA genotype was higher than CA and CC genotypes in controls. No significant effect of II, IV and VV genotypes was found in lipid profiles. Conclusion: No significant association was found between CETP I405V polymorphism and increased risk of CAD in Azeri population studied. AA genotype of -629C/A increased HDL but the risk of CAD in this genotype might be higher than CC genotype.
Keywords: Cholesteryl ester transfer protein (CETP) gene, I405V, High-density lipoprotein (HDL) cholesterol, -629C/A
Type of Study: Full Length/Original Article |
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