:: Volume 15, Issue 4 (10-2011) ::
IBJ 2011, 15(4): 164-167 Back to browse issues page
Effect of Oleuropein on Tissue Myeloperoxidase Activity in Experimental Spinal Cord Trauma
Ali Reza Khalatbary , Hassan Ahmadvand
Abstract:  

Background: Neutrophil infiltration plays an important role in inflammatory reactions following spinal cord injury (SCI) and these cells cause substantial secondary tissue damage. The purpose of this study was to determine the effect of oleuropein (OE) on myeloperoxidase (MPO) activity as an index of neutrophil infiltration. Methods: Rats were randomly divided into four groups of 7 rats each as follows: sham-operated group, trauma group, and OE treatment groups (20 mg/kg, i.p., immediately and 1 hour after SCI). Spinal cord samples were taken 24 hours after injury and studied for determination of MPO activity. Results: The results showed that MPO activity was significantly decreased in OE-treated rats. Conclusion: On the basis of our findings, we propose that OE may be effective in protecting rat spinal cord from secondary damage by modulating of neutrophil infiltration.

Keywords: Oleuropein (OE), Neutrophil infiltration, Myeloperoxidase
Full-Text [PDF 94 kb]      
Type of Study: Short Communication | Subject: Related Fields
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA code



XML     Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Khalatbary A R, Ahmadvand H. Effect of Oleuropein on Tissue Myeloperoxidase Activity in Experimental Spinal Cord Trauma. IBJ. 2011; 15 (4) :164-167
URL: http://ibj.pasteur.ac.ir/article-1-614-en.html


Volume 15, Issue 4 (10-2011) Back to browse issues page
Persian site map - English site map - Created in 0.18 seconds with 37 queries by YEKTAWEB 3767