Volume 6, Issue 4 (10-2002)                   IBJ 2002, 6(4): 141-145 | Back to browse issues page

XML Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Sayyah M, Peirovi A, Kamalinejad M. Anti-Nociceptive Effect of the Fruit Essential Oil of Cuminum cyminum L. in Rat. IBJ 2002; 6 (4) :141-145
URL: http://ibj.pasteur.ac.ir/article-1-560-en.html
Abstract:  
Cuminum cyminum Linn. (Umbelliferae) is a plant, which has been used as a toothache remedy in folk medicine of Iran. In this study, the potential anti-nociceptive and anti-inflammatory activities of the fruit essential oil of C. cyminum has been evaluated in chemical (formalin test) and thermal (tail-flick test) models of nociception and formalin model of acute inflammation in rats and mice. The essential oil at the doses ranging between 0.0125 and 0.20 ml/kg exhibited a significant and dose-dependent analgesic effect in the model of chronic and inflammatory pain. However, the essential oil was devoid of anti-inflammatory activity. Moreover, the essential oil had no analgesic effect in tail flick test as a model of acute pain. The LD50 value of 0.59 ml/kg was obtained for the essential oil. This low toxicity of the essential oil makes it worthy for further studies
Type of Study: Full Length/Original Article |

Add your comments about this article : Your username or Email:
CAPTCHA

Send email to the article author


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2024 CC BY-NC 4.0 | Iranian Biomedical Journal

Designed & Developed by : Yektaweb