Iranian
Biomedical Journal
Volume 7, Issue 1 (1-2003)
IBJ 2003, 7(1): 29-33 |
Back to browse issues page
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Samiee S M, Moazami N, Haghighi S, Aziz Mohseni F, Mirdamadi S, Bakhtiari M R. Screening of Lovastatin Production by Filamentous Fungi. IBJ 2003; 7 (1) :29-33
URL: http://ibj.pasteur.ac.ir/article-1-550-en.html
URL: http://ibj.pasteur.ac.ir/article-1-550-en.html
Siamak M Samiee 
, Nasrin Moazami , Saeid Haghighi , Farzaneh Aziz Mohseni , Saeid Mirdamadi , Mohammad Reza Bakhtiari
, Nasrin Moazami , Saeid Haghighi , Farzaneh Aziz Mohseni , Saeid Mirdamadi , Mohammad Reza Bakhtiari
Abstract:
In the present study, 110 fungal strains of Persian Type Culture Collection (PTCC) including some selected strains isolated in various screening projects were tested for their potentiality to produce lovastatin, a competitive inhibitor of 3-hydroxy-3-methylglutaryl-CoA reductase (HMG-CoA reduc-tase), the rate-limiting enzyme of cholesterol biosynthesis. The fungal strains were cultivated in a two-stage submerged fermentation followed by screening by TLC. All positive results were evaluated by confirmatory HPLC. Nine species of four genera were found to be lovastatin producers. Aspergillus terreus was the best lovastatin producing strain with a level of 55 mg lovastatin per liter of screening production medium
Type of Study: Full Length/Original Article |
Send email to the article author
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
IBJ is a member of Committee on Publication Ethics (COPE)
and follows its guidelines |
The articles of this journal are licensed under
a Creative Commons Attribution-NonDerivatives 4.0 International License. .png) |
 IBJ is owned and published by Pasteur Institute of Iran |