Volume 7, Issue 3 (7-2003)                   ibj 2003, 7(3): 119-126 | Back to browse issues page

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Sinha R K, Ray A K. Effect of p-CPA Pretreatment on EEG Power Spectra in Experimental Open Brain Injury in Rats. ibj. 2003; 7 (3) :119-126
URL: http://ibj.pasteur.ac.ir/article-1-533-en.html
Continuous four hours EEG (electroencephalogram) recordings and its power spectrum analysis using fast fourier transform (FFT) in urethane anesthetized male Charles Foster rats were performed in two groups: open brain injury and p-CPA (para-Chlorophenylalanine) pretreated before brain injury, respectively, and compared with the EEG power spectrum of control rats. The EEG power spectrum analysis showed that there was a faster recovery in p-CPA pretreated group than the injury group of rats. The results showed that the p-CPA (a 5-HT inhibitor) prevents pathological changes following brain injury. Simultaneously, the inference can also be drawn that EEG power spectrum analysis is a useful technique for monitoring the brain injury and its recovery following pharmacological treatments
Type of Study: Full Length |

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