:: Volume 8, Issue 1 (1-2004) ::
IBJ 2004, 8(1): 41-45 Back to browse issues page
Downregulation of IL-12 Production in Healthy Non-Responder Neonates to Recombinant Hepatitis B Vaccine
Abdollah Jafarzadeh , Golam A Kardar , Jalal Khoshnoodi , Fazel Shokri
Abstract:  
A proportion of healthy neonates and adults fail to develop a protective antibody response to recombinant hepatitis B (HB) vaccine. Unresponsiveness to vaccination could be attributed to defect in a number of immunological regulatory mechanisms. In this study, IL-12 was quantitated in culture supernatant following in vitro stimulation of peripheral blood mononuclear cells isolated from a group of responder and non-responder neonates. Our results indicate significantly decreased production of HBsAg-induced IL-12 in non-responder subjects compared to responders (P<0.01). Since IL-12 is produced mainly by antigen presenting cells (APC) and is considered to be crucial for initiation and polarization of CD4+ T-cell function, therefore, our findings could be interpreted to imply APC dysfunction in non-responder vaccinees
Keywords: IL-12, hepatitis B, vaccination, neonates
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Type of Study: Full Length |
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Jafarzadeh A, Kardar G A, Khoshnoodi J, Shokri F. Downregulation of IL-12 Production in Healthy Non-Responder Neonates to Recombinant Hepatitis B Vaccine. IBJ. 2004; 8 (1) :41-45
URL: http://ibj.pasteur.ac.ir/article-1-510-en.html


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