:: Volume 8, Issue 3 (7-2004) ::
IBJ 2004, 8(3): 143-147 Back to browse issues page
The Effect of Gnidilatimonoein from Daphne mucronata, on the Adhesive Property of Human Platelets
Manijeh Mianabadi , Razieh Yazdanparast
Abstract:  
The adhesive interaction between tumor cells and the host cells or the extracellular matrix plays a crucial role in tumor metastasis. To evaluate the mediation of cell adhesion by Daphne mucronata, an anti-cancer medicinal plant in Iranian folk medicine, the adhesion of thrombin activated human platelets to the cultured monocytes or HL-60 cells was investigated under the effect of the plant extract (0.54 mg/ml) or one of its purified components (gnidilatimonoein, 0.94 ┬ÁM). Treatment of the platelets with the plant extract or the active component, for various time intervals, followed by their activation by thrombin resulted in 80-90% reduction in the number of monocytes with more than 10 attached platelets. Similarly, under almost all identical conditions, the adhesion of the activated platelets to HL-60 cells was decreased by 90%. The adhesion of thrombin activated human platelets to the plant treated HL-60 cells was also reduced significantly (by 95%). These data clearly indicate that Daphne mucronata is capable of mediating tumor metastasis through effecting cell adhesion properties of the cells
Keywords: Cell adhesion, D. mucronata, Cancer, Metastasis
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Mianabadi M, Yazdanparast R. The Effect of Gnidilatimonoein from Daphne mucronata, on the Adhesive Property of Human Platelets. IBJ. 2004; 8 (3) :143-147
URL: http://ibj.pasteur.ac.ir/article-1-500-en.html


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