Iranian
Biomedical Journal
Volume 10, Issue 2 (4-2006)
IBJ 2006, 10(2): 85-91 |
Back to browse issues page
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Farshad S, Alborzi A, Japoni A, Hayati M, Saberfirouzi M, Bagheri Lankarani K, et al . Discrimination of Dominant H. pylori Strains Isolated from Patients with Different Gastroduodenal Pathologies by Protein Profiling. IBJ 2006; 10 (2) :85-91
URL: http://ibj.pasteur.ac.ir/article-1-354-en.html
URL: http://ibj.pasteur.ac.ir/article-1-354-en.html
Shohreh Farshad * 
, Abdolvahab Alborzi , Aziz Japoni , Masoumeh Hayati , Mehdi Saberfirouzi , Kamran Bagheri Lankarani , AliReza Taghavi , Jalil Nasiri , Noreddin Rafatpour
, Abdolvahab Alborzi , Aziz Japoni , Masoumeh Hayati , Mehdi Saberfirouzi , Kamran Bagheri Lankarani , AliReza Taghavi , Jalil Nasiri , Noreddin Rafatpour
Abstract:
It is not clear what factors determine divergent outcomes of infections caused by H. pylori . In the present study, the protein profiles of different strains of H. pylori, isolated from three groups of patients with ulcerative disease, non-ulcerative gastritis and cancer disease, were analyzed using 1DSDS-PAGE. The patterns of different H. pylori strains were highly divergent. About 30.76% (7 bands) of the 26 observed protein bands were common in all strains isolated from 3 groups of the patients. While the similarity for the strains inside each group were 75% (15 from 20), 76.47% (13 from 17) and 78.57% (11 from 14) for cancerous, ulcerative and nonulcerative group, respectively. Some of the observed bands were significantly specific for each group. Therefore, we speculated that some H. pylori strains might be more associated with a specific disease than others, giving the clustering of some, but not all, strains within each disease group. In conclusion, this study showed that protein profile can be a characteristic in discrimination of dominant strains in different gastric clinical status. Specific and dominant proteins of different strains isolated from three groups of patients under study were candidates for further exploration for laboratory tests, which analyze disease-specific H. pylori strains, and for diagnosis of the different diseases and outcomes associated with this widespread bacterium.
Type of Study: Full Length/Original Article |
Send email to the article author
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
IBJ is a member of Committee on Publication Ethics (COPE)
and follows its guidelines |
The articles of this journal are licensed under
a Creative Commons Attribution-NonDerivatives 4.0 International License. .png) |
 IBJ is owned and published by Pasteur Institute of Iran |