:: Volume 22, Issue 5 (9-2018) ::
IBJ 2018, 22(5): 294-302 Back to browse issues page
Effects of Major Epigenetic Factors on Systemic Lupus Erythematosus
Shirin Farivar , Fateme Shaabanpour Aghamaleki
Abstract:  
The pathogenesis of systemic lupus erythematosus (SLE) is influenced by both genetic factors and epigenetic modifications; the latter is a result of exposure to various environmental factors. Epigenetic modifications affect gene expression and alter cellular functions without modifying the genomic sequences. CpG-DNA methylation, histone modifications, and miRNAs are the main epigenetic factors of gene regulation. In SLE, global and gene-specific DNA methylation changes have been demonstrated to occur in CD4+ T-cells. Moreover, histone acetylation and deacetylation inhibitors reverse the expression of multiple genes involved in SLE, indicating histone modification in SLE. Autoreactive T-cells and B-cells have been shown to alter the patterns of epigenetic changes in SLE patients. Understanding the molecular mechanisms involved in the pathogenesis of SLE is critical for the introduction of effective, target-directed and tolerated therapies. In this review, we summarize the recent findings that highlight the importance of epigenetic modifications and their mechanisms in SLE. 
Keywords: DNA methylation, Epigenesis, Histones, microRNAs, Systemic lupus erythematosus
Full-Text [PDF 890 kb]      
Type of Study: Review Article | Subject: Tissue Engineering and Cell Biology
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Farivar S, Shaabanpour Aghamaleki F. Effects of Major Epigenetic Factors on Systemic Lupus Erythematosus. IBJ. 2018; 22 (5) :294-302
URL: http://ibj.pasteur.ac.ir/article-1-2427-en.html


Volume 22, Issue 5 (9-2018) Back to browse issues page
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