:: Volume 21, Number 5 (9-2017) ::
IBJ 2017, 21(5): 303-311 Back to browse issues page
Expression Study and Clinical Correlations of MYC and CCAT2 in Breast Cancer Patients
Shaghayegh Sarrafzadeh, Lobat Geranpayeh, Behnoosh Tasharrofi, Mohammad Soudyab, Elahe Nikpayam, Mostafa Iranpour, Reza Mirfakhraie, Jalal Gharesouran, Somayyeh Ghafouri-Fard, Soudeh Ghafouri-Fard
Abstract:  

Background: Colon cancer-associated transcript 2 (CCAT2) is a newly recognized lncRNA transcribed from the 8q24 genomic region. It functions as an oncogene in various types of cancers including breast cancer, in which it affects Wnt/β-catenin pathway. Previous studies have shown a putative interaction between this lncRNA and MYC proto-oncogene. Methods: In the current study, we evaluated the expression of CCAT2 in breast cancer tissues with regards to the expression of its target MYC. In addition, we assessed the relationship between CCAT2 and MYC expression levels in tumor tissues and the clinical prognostic characteristics of breast cancer patients. Results: MYC expression levels were significantly up-regulated in tumor tissues compared with adjacent non-cancerous tissues (ANCTs), while such analysis showed no statistically significant difference between these two tissue types in CCAT2 expression. Starkly increased CCAT2 gene expression levels were found in 12/48 (25%) of cancer tissue samples compared with their corresponding ANCTs. Furthermore, significant inverse correlations were found between CCAT2 expression and stage, as well as lymph node involvement. Besides, a significant inverse correlation was found between the relative MYC expression in tumor tissues compared with their corresponding ANCTs and disease stage. Conclusions: These results highlight the significance of MYC and CCAT2 expressions in the early stages of breast cancer development and suggest a potentially significant role for CCAT2 in a subset of breast cancer patients, which could applied as a potential therapeutic target in these patients.

Keywords: Long non-coding RNA, Breast cancer, c-MYC
Full-Text [PDF 880 kb]      
Type of Study: Full Length | Subject: Cancer Biology
Add your comments about this article
Your username or email:

Write the security code in the box >



DOI: 10.18869/acadpub.ibj.21.5.303
PMID: 28480695
PMCID: PMC5548962


XML     Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Sarrafzadeh S, Geranpayeh L, Tasharrofi B, Soudyab M, Nikpayam E, Iranpour M, et al . Expression Study and Clinical Correlations of MYC and CCAT2 in Breast Cancer Patients . IBJ. 2017; 21 (5) :303-311
URL: http://ibj.pasteur.ac.ir/article-1-2036-en.html
Volume 21, Number 5 (9-2017) Back to browse issues page
Persian site map - English site map - Created in 0.18 seconds with 889 queries by yektaweb 3501